1. Catalog
  2. Nodes
  3. complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A))

complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

Assembly and structure of protein phosphatase 2A v1.0.0

In-Edges 0

Out-Edges 4

complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) hasComponent p(HGNC:PPP2CA, pmod(Me)) View Subject | View Object

Appears in Networks:

complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) hasComponent p(HGNC:PPP2R1A) View Subject | View Object

Appears in Networks:

complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) View Subject | View Object

In fact, competition experiments using recombinant proteins suggested that, compared to the unmethylated form, the methylated PP2A core enzyme exhibited a higher binding affinity for the B subunit PubMed:19277525

Appears in Networks:

complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) increases complex(GO:"protein phosphatase type 2A complex") View Subject | View Object

In addition, the methylated carboxy-terminus might help recruit assembly factors that actively promote assembly of the PP2A holoenzymes in cells. PubMed:19277525

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.