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Protein phosphatase 2A dysfunction in Alzheimer’s disease 1.0.0

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Provenance

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charles.hoyt@scai.fraunhofer.de at 2019-03-15 15:43:52.100415
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
122
Number Edges
411
Number Components
1
Network Density
0.0278417558596396
Average Degree
3.36885245901639
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0 38%
Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0 33%
Assembly and structure of protein phosphatase 2A v1.0.0 32%
Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5 v1.0.0 30%
Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers v1.0.0 26%
Axonal Transport, Tau Protein, and Neurodegeneration in Alzheimer’s Disease v1.0.0 24%
PP2A and Alzheimer Disease v1.0.0 23%
Anatabine Attenuates Tau Phosphorylation and Oligomerization in P301S Tau Transgenic Mice v1.0.0 22%
Tau Modifications v1.9.5 22%
Inflammasome Involvement in Alzheimer’s Disease v1.0.0 22%

Sample Edges

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

p(HGNC:APP) hasVariant p(HGNC:APP, pmod(Ph)) View Subject | View Object

p(HGNC:APP) hasVariant p(HGNC:APP, pmod(Ph, Thr, 668)) View Subject | View Object

complex(p(HGNC:FYN), p(HGNC:MAPT)) hasComponent p(HGNC:FYN) View Subject | View Object

complex(p(HGNC:FYN), p(HGNC:MAPT)) hasComponent p(HGNC:MAPT) View Subject | View Object

Sample Nodes

a(CHEBI:"amyloid-beta")

In-Edges: 423 | Out-Edges: 245 | Children: 5 | Explore Neighborhood | Download JSON

bp(GO:cognition)

In-Edges: 111 | Out-Edges: 35 | Explore Neighborhood | Download JSON

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON

p(HGNC:APP)

In-Edges: 106 | Out-Edges: 69 | Explore Neighborhood | Download JSON

p(HGNC:MAPT)

In-Edges: 477 | Out-Edges: 480 | Classes: 11 | Children: 27 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.