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a(MESH:"haptoglobin-hemoglobin complex")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
haptoglobin-hemoglobin complex
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 7

p(HGNC:HBB) negativeCorrelation a(MESH:"haptoglobin-hemoglobin complex") View Subject | View Object

Because of its large molecular size, this complex is maintained in the intravascular space, preventing the association of otherwise free Hb with nitric oxide (NO; Reiter et al., 2002) and inhibiting the release of free heme (Melamed-Frank et al., 2001). PubMed:24904418

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Text Location
Review

complex(a(MESH:"haptoglobin-hemoglobin complex"), p(HGNC:CD163)) hasComponent a(MESH:"haptoglobin-hemoglobin complex") View Subject | View Object

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p(HGNC:CD163) increases deg(a(MESH:"haptoglobin-hemoglobin complex")) View Subject | View Object

The haptoglobin–haemoglobin complex is recognized by the haemoglobin scavenger receptor, CD163, on the surface of monocytes/macrophages, which mediates haptoglobin–haemoglobin endocytosis and degradation (Kristiansen et al, 2001). PubMed:25307023

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Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

p(HGNC:CD163) decreases a(MESH:"haptoglobin-hemoglobin complex") View Subject | View Object

Haptoglobin (Hp) is perhaps the most well investigated Hb-clearing molecule. It binds cell-free Hb in plasma [20,21] and the resulting Hp-Hb complex is cleared from blood via binding to the macrophage receptor CD163 [22]. PubMed:26368565

Appears in Networks:
Annotations
MeSH
Placenta
Text Location
Introduction

p(HGNC:CD163) increases deg(a(MESH:"haptoglobin-hemoglobin complex")) View Subject | View Object

Haptoglobin binds to hemoglobin dimers and forms a high-molecular weight haptoglobin-hemoglobin complex, which is cleared from the circulation after binding to the CD163 receptor on hepatic and splenic macrophages (12). PubMed:28314763

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Text Location
Introduction

p(HGNC:HP) positiveCorrelation a(MESH:"haptoglobin-hemoglobin complex") View Subject | View Object

Haptoglobin (Hp) is perhaps the most well investigated Hb-clearing molecule. It binds cell-free Hb in plasma [20,21] and the resulting Hp-Hb complex is cleared from blood via binding to the macrophage receptor CD163 [22]. PubMed:26368565

Appears in Networks:
Annotations
MeSH
Placenta
Text Location
Introduction

path(MESH:"Pre-Eclampsia") positiveCorrelation a(MESH:"haptoglobin-hemoglobin complex") View Subject | View Object

A statistically significant increase in the mean Hp-HbF concentration was observed for women with PE as compared to controls (p-value 0.018). PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Placenta
MeSH
Pre-Eclampsia
Text Location
Results

Out-Edges 7

a(MESH:"haptoglobin-hemoglobin complex") decreases p(HGNC:HP) View Subject | View Object

Formation of large amounts of haptoglobin– haemoglobin complexes rapidly depletes haptoglobin. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

a(MESH:"haptoglobin-hemoglobin complex") decreases path(MESH:Inflammation) View Subject | View Object

For example, Hp 2-2 has been associated with an increased susceptibility to diabetic cardiovascular disease; uptake of Hb-Hp(1-1) complexes by CD163 receptors is reportedly faster and its binding results in increased concentrations of anti-inflammatory mediators than Hb-Hp(2-2) complexes; and the angiogenic potency of Hp 2-2 is reportedly greater than that of Hp 1-1 [18]. PubMed:24486321

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Text Location
Introduction

a(MESH:"haptoglobin-hemoglobin complex") decreases a(HM:"oxidative reactions") View Subject | View Object

This result is in accord with recent work, which showed that Hp binding to Hb prevents oxidative damage to the globin. PubMed:24486321

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MeSH
Anemia, Sickle Cell
Text Location
Discussion

a(MESH:"haptoglobin-hemoglobin complex") negativeCorrelation p(HGNC:HBB) View Subject | View Object

Because of its large molecular size, this complex is maintained in the intravascular space, preventing the association of otherwise free Hb with nitric oxide (NO; Reiter et al., 2002) and inhibiting the release of free heme (Melamed-Frank et al., 2001). PubMed:24904418

Appears in Networks:
Annotations
Text Location
Review

a(MESH:"haptoglobin-hemoglobin complex") decreases p(HGNC:HBB) View Subject | View Object

Macrophages and liver cells capture large HP-Hb complexes clearing the plasma from free hemoglobin. PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Introduction

a(MESH:"haptoglobin-hemoglobin complex") positiveCorrelation p(HGNC:HP) View Subject | View Object

Haptoglobin (Hp) is perhaps the most well investigated Hb-clearing molecule. It binds cell-free Hb in plasma [20,21] and the resulting Hp-Hb complex is cleared from blood via binding to the macrophage receptor CD163 [22]. PubMed:26368565

Appears in Networks:
Annotations
MeSH
Placenta
Text Location
Introduction

a(MESH:"haptoglobin-hemoglobin complex") positiveCorrelation path(MESH:"Pre-Eclampsia") View Subject | View Object

A statistically significant increase in the mean Hp-HbF concentration was observed for women with PE as compared to controls (p-value 0.018). PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Placenta
MeSH
Pre-Eclampsia
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.