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p(HGNC:CD163)

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Entity

Name
CD163
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(CHEBI:"desferrioxamine B") negativeCorrelation p(HGNC:CD163) View Subject | View Object

DFX treatment also caused a significant reduction in infiltrating CD163-positive and HO-1 positive cell in the hematoma at day 3 (Figs. 6A and B) and day 7 (Suppl Figures II & III). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

a(HM:erythrophagocytosis) positiveCorrelation p(HGNC:CD163) View Subject | View Object

Evidence suggested that CD163 acts as a hemoglobin scavenger receptor on microglia/macrophage with a role in erythrophagocytosis. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

complex(a(MESH:"haptoglobin-hemoglobin complex"), p(HGNC:CD163)) hasComponent p(HGNC:CD163) View Subject | View Object

Appears in Networks:

path(MESH:"Pre-Eclampsia") positiveCorrelation p(HGNC:CD163) View Subject | View Object

Soluble, shedded CD163, the macrophage receptor mediating elimination of the Hp-Hb complex, was analyzed in plasma [40–42]. The analysis showed a small but not statistically significant (p-value 0.37) increase in the PE group as compared to the controls (Table 3). PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Results

path(MESH:Hematoma) positiveCorrelation p(HGNC:CD163) View Subject | View Object

CD163 and HO-1 positive cells infiltrated into the hematoma from edge to center after ICH (Figs. 4A & 4B). A significant increase of CD163 cells was found at day 3. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

Out-Edges 8

p(HGNC:CD163) increases deg(a(MESH:"haptoglobin-hemoglobin complex")) View Subject | View Object

The haptoglobin–haemoglobin complex is recognized by the haemoglobin scavenger receptor, CD163, on the surface of monocytes/macrophages, which mediates haptoglobin–haemoglobin endocytosis and degradation (Kristiansen et al, 2001). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

p(HGNC:CD163) decreases a(MESH:"haptoglobin-hemoglobin complex") View Subject | View Object

Haptoglobin (Hp) is perhaps the most well investigated Hb-clearing molecule. It binds cell-free Hb in plasma [20,21] and the resulting Hp-Hb complex is cleared from blood via binding to the macrophage receptor CD163 [22]. PubMed:26368565

Appears in Networks:
Annotations
MeSH
Placenta
Text Location
Introduction

p(HGNC:CD163) increases deg(a(MESH:"haptoglobin-hemoglobin complex")) View Subject | View Object

Haptoglobin binds to hemoglobin dimers and forms a high-molecular weight haptoglobin-hemoglobin complex, which is cleared from the circulation after binding to the CD163 receptor on hepatic and splenic macrophages (12). PubMed:28314763

Appears in Networks:
Annotations
Text Location
Introduction

p(HGNC:CD163) positiveCorrelation path(MESH:"Pre-Eclampsia") View Subject | View Object

Soluble, shedded CD163, the macrophage receptor mediating elimination of the Hp-Hb complex, was analyzed in plasma [40–42]. The analysis showed a small but not statistically significant (p-value 0.37) increase in the PE group as compared to the controls (Table 3). PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Results

p(HGNC:CD163) positiveCorrelation path(MESH:Hematoma) View Subject | View Object

CD163 and HO-1 positive cells infiltrated into the hematoma from edge to center after ICH (Figs. 4A & 4B). A significant increase of CD163 cells was found at day 3. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

p(HGNC:CD163) negativeCorrelation a(CHEBI:"desferrioxamine B") View Subject | View Object

DFX treatment also caused a significant reduction in infiltrating CD163-positive and HO-1 positive cell in the hematoma at day 3 (Figs. 6A and B) and day 7 (Suppl Figures II & III). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

p(HGNC:CD163) positiveCorrelation a(HM:erythrophagocytosis) View Subject | View Object

Evidence suggested that CD163 acts as a hemoglobin scavenger receptor on microglia/macrophage with a role in erythrophagocytosis. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

p(HGNC:CD163) increases p(HGNC:HMOX1) View Subject | View Object

CD163 mediated hemoglobin/hematoma clearance is involved in the induction of HO-1, a rate-limiting enzyme for heme degradation 26. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.