Macrophages

Name: Macrophages
Namespace Keyword: MeSHAnatomy
Namespace: MeSH
Namespace Version: 20170511
Namespace URL: https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

act(a(CHEBI:nicotine)) increases act(p(HGNC:STAT3)) View Subject | View Object

Downstream from the nicotine-stimulated kinases, a number of transcription factors have been shown to be activated. Among these factors are the cAMP response element binding protein (CREB) and the activating transcription factor 2 (ATF-2) in PC12 cells (211, 337, 460), the Ets-like transcription factor Elk-1 in the rat hippocampus (349), and the signal transducer and activator of transcription (STAT3) in macrophages and skin cells (114, 354). PubMed:19126755

Appears in Networks:

albuquerque2009 v1.0.0

Annotations

MeSH: Macrophages
MeSH: Skin
Text Location: Review

a(CHEBI:heme) increases act(a(CHEBI:Peroxidase)) View Subject | View Object

It is well known that in the presence of H2O2 hemoglobin exhibits a peroxidase-like activity, catalyzed by the heme moiety. PubMed:28088643

Appears in Networks:

Heme Curation v0.0.1-dev

Annotations

MeSH: Liver
MeSH: Macrophages
MeSH: Anemia, Sickle Cell
Text Location: Results

a(MESH:"haptoglobin-hemoglobin complex") decreases p(HGNC:HBB) View Subject | View Object

Macrophages and liver cells capture large HP-Hb complexes clearing the plasma from free hemoglobin. PubMed:28088643

Appears in Networks:

Heme Curation v0.0.1-dev

Annotations

MeSH: Liver
MeSH: Macrophages
MeSH: Anemia, Sickle Cell
Text Location: Introduction

p(HGNC:HPX) causesNoChange act(a(CHEBI:Peroxidase)) View Subject | View Object

However, no changes in peroxidase activity were observed after incubation with haptoglobin or hemopexin (Fig. 2). PubMed:28088643

Appears in Networks:

Heme Curation v0.0.1-dev

Annotations

MeSH: Liver
MeSH: Macrophages
MeSH: Anemia, Sickle Cell
Text Location: Results

complex(a(CHEBI:heme), p(INTERPRO:"NEAT domain")) decreases act(a(CHEBI:Peroxidase)) View Subject | View Object

At the same time, heme bound to NEAT does not catalyze the peroxidase reaction due to inability to interact with H2O2. PubMed:28088643

Appears in Networks:

Heme Curation v0.0.1-dev

Annotations

MeSH: Liver
MeSH: Macrophages
MeSH: Anemia, Sickle Cell
Text Location: Results

Showing 5 of 13 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.