1. Catalog
  2. Nodes
  3. bp(GO:"action potential initiation")

bp(GO:"action potential initiation")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
action potential initiation
Namespace
go
Namespace Version
20181221
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/73688d6dc24e309fca59a1340dc9ee971e9f3baa/external/go-names.belns

Appears in Networks 3

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0

In-Edges 5

act(p(HGNC:CHRNA7)) increases bp(GO:"action potential initiation") View Subject | View Object

It is noteworthy that, via such mechanisms, alpha7 nAChR activation could trigger rebound burst firing in SLM interneurons even in the absence of excitation (256). Burst firing in SLM interneurons suppresses spikes in pyramidal neurons evoked by stimulation of Schaffer collaterals (134), and, thereby allows selective activation of the pyramidal cells via the perforant pathway. PubMed:19126755

Appears in Networks:
Annotations
Uberon
hippocampus stratum lacunosum moleculare
Text Location
Review

complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) association bp(GO:"action potential initiation") View Subject | View Object

It is possible that the presence of CHT1 in the membrane of synaptic vesicles and the consequent increase in CHT1 relocation to the plasma membrane following neuronal depolarization could explain why an increase in neuronal firing promotes increased choline reuptake and, thus, ACh synthesis PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

a(MESH:Glutamates) increases bp(GO:"action potential initiation") View Subject | View Object

By acting on the α7 receptors in glutamate terminals, acutely administrated nicotine stimu- lates the release of glutamate, which facilitates the burst fir- ing of VTA DA neurons and eventually leads to LTP,and increases the firing rate of the GABAergic neurons of the rostromedial tegmental nucleus PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(MESH:Nicotine) increases bp(GO:"action potential initiation") View Subject | View Object

nicotine modulates the shift towards burst firing and increases DA release in the NAc PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

p(MESH:"Receptors, Nicotinic") association bp(GO:"action potential initiation") View Subject | View Object

nAChRs are expressed also at the somatodendritic postsynaptic site, where they regulate neuron depolarisation, firing and long- term potentiation [9]. Moreover these receptors are also in- volved in proliferation, differentiation and migration of neu- ral progenitors PubMed:28901280

Appears in Networks:

Out-Edges 8

bp(GO:"action potential initiation") decreases a(MESH:"Electric Stimulation", loc(GO:"Schaffer axon collateral")) View Subject | View Object

It is noteworthy that, via such mechanisms, alpha7 nAChR activation could trigger rebound burst firing in SLM interneurons even in the absence of excitation (256). Burst firing in SLM interneurons suppresses spikes in pyramidal neurons evoked by stimulation of Schaffer collaterals (134), and, thereby allows selective activation of the pyramidal cells via the perforant pathway. PubMed:19126755

Appears in Networks:
Annotations
Uberon
hippocampus stratum lacunosum moleculare
Text Location
Review

bp(GO:"action potential initiation") increases act(a(MESH:"Perforant Pathway")) View Subject | View Object

It is noteworthy that, via such mechanisms, alpha7 nAChR activation could trigger rebound burst firing in SLM interneurons even in the absence of excitation (256). Burst firing in SLM interneurons suppresses spikes in pyramidal neurons evoked by stimulation of Schaffer collaterals (134), and, thereby allows selective activation of the pyramidal cells via the perforant pathway. PubMed:19126755

Appears in Networks:
Annotations
Uberon
hippocampus stratum lacunosum moleculare
Text Location
Review

bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) View Subject | View Object

Interestingly, it has been demonstrated that an increase in neuronal firing can lead to an increase in choline uptake and in the synthesis of ACh PubMed:26813123

Appears in Networks:

bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) View Subject | View Object

It is possible that the presence of CHT1 in the membrane of synaptic vesicles and the consequent increase in CHT1 relocation to the plasma membrane following neuronal depolarization could explain why an increase in neuronal firing promotes increased choline reuptake and, thus, ACh synthesis PubMed:26813123

Appears in Networks:
Annotations
MeSH
Membranes
MeSH
Synaptic Vesicles

bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) View Subject | View Object

Interestingly, it has been demonstrated that an increase in neuronal firing can lead to an increase in choline uptake and in the synthesis of ACh PubMed:26813123

Appears in Networks:

bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) View Subject | View Object

It is possible that the presence of CHT1 in the membrane of synaptic vesicles and the consequent increase in CHT1 relocation to the plasma membrane following neuronal depolarization could explain why an increase in neuronal firing promotes increased choline reuptake and, thus, ACh synthesis PubMed:26813123

Appears in Networks:
Annotations
MeSH
Membranes
MeSH
Synaptic Vesicles

bp(GO:"action potential initiation") association complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) View Subject | View Object

It is possible that the presence of CHT1 in the membrane of synaptic vesicles and the consequent increase in CHT1 relocation to the plasma membrane following neuronal depolarization could explain why an increase in neuronal firing promotes increased choline reuptake and, thus, ACh synthesis PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

bp(GO:"action potential initiation") association p(MESH:"Receptors, Nicotinic") View Subject | View Object

nAChRs are expressed also at the somatodendritic postsynaptic site, where they regulate neuron depolarisation, firing and long- term potentiation [9]. Moreover these receptors are also in- volved in proliferation, differentiation and migration of neu- ral progenitors PubMed:28901280

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.