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Membranes

Name
Membranes
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

act(a(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:synapse)) View Subject | View Object

Stimulation of nicotinic receptors present at the CNS presynaptic neuronal membrane leads to an increase in presynaptic Ca2+ concentration, which may facilitate the release of a number of neurotransmitters, such as glutamate, GABA, dopamine, serotonin, norepinephrine, as well as ACh PubMed:26813123

Appears in Networks:
Annotations
MeSH
Central Nervous System
MeSH
Membranes
MeSH
Neurons

p(HGNC:SLC5A7) increases a(CHEBI:acetylcholine) View Subject | View Object

It is possible that the presence of CHT1 in the membrane of synaptic vesicles and the consequent increase in CHT1 relocation to the plasma membrane following neuronal depolarization could explain why an increase in neuronal firing promotes increased choline reuptake and, thus, ACh synthesis PubMed:26813123

Appears in Networks:
Annotations
MeSH
Membranes
MeSH
Synaptic Vesicles

bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) View Subject | View Object

It is possible that the presence of CHT1 in the membrane of synaptic vesicles and the consequent increase in CHT1 relocation to the plasma membrane following neuronal depolarization could explain why an increase in neuronal firing promotes increased choline reuptake and, thus, ACh synthesis PubMed:26813123

Appears in Networks:
Annotations
MeSH
Membranes
MeSH
Synaptic Vesicles

a(MESH:"Receptors, Nicotinic") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) View Subject | View Object

In the CNS, most of the nicotinic receptors are expressed at the presynaptic neuronal membrane and their main role is to regulate the release of neurotransmitters, whereas nicotinic receptors expressed in the peripheral nervous system are mainly post-synaptic PubMed:26813123

Appears in Networks:
Annotations
MeSH
Central Nervous System
MeSH
Membranes
MeSH
Neurons

p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) View Subject | View Object

It is possible that the presence of CHT1 in the membrane of synaptic vesicles and the consequent increase in CHT1 relocation to the plasma membrane following neuronal depolarization could explain why an increase in neuronal firing promotes increased choline reuptake and, thus, ACh synthesis PubMed:26813123

Appears in Networks:
Annotations
MeSH
Membranes
MeSH
Synaptic Vesicles

Showing 5 of 6 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.