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hippocampus stratum lacunosum moleculare

Name
hippocampus stratum lacunosum moleculare
Namespace Keyword
Anatomy
Namespace
Uberon
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/anatomy/anatomy-20170511.belanno

Sample Annotated Edges 4

act(p(HGNC:CHRNA7)) increases bp(GO:"action potential initiation") View Subject | View Object

It is noteworthy that, via such mechanisms, alpha7 nAChR activation could trigger rebound burst firing in SLM interneurons even in the absence of excitation (256). Burst firing in SLM interneurons suppresses spikes in pyramidal neurons evoked by stimulation of Schaffer collaterals (134), and, thereby allows selective activation of the pyramidal cells via the perforant pathway. PubMed:19126755

Appears in Networks:
Annotations
Uberon
hippocampus stratum lacunosum moleculare
Text Location
Review

bp(GO:"action potential initiation") decreases a(MESH:"Electric Stimulation", loc(GO:"Schaffer axon collateral")) View Subject | View Object

It is noteworthy that, via such mechanisms, alpha7 nAChR activation could trigger rebound burst firing in SLM interneurons even in the absence of excitation (256). Burst firing in SLM interneurons suppresses spikes in pyramidal neurons evoked by stimulation of Schaffer collaterals (134), and, thereby allows selective activation of the pyramidal cells via the perforant pathway. PubMed:19126755

Appears in Networks:
Annotations
Uberon
hippocampus stratum lacunosum moleculare
Text Location
Review

bp(GO:"action potential initiation") increases act(a(MESH:"Perforant Pathway")) View Subject | View Object

It is noteworthy that, via such mechanisms, alpha7 nAChR activation could trigger rebound burst firing in SLM interneurons even in the absence of excitation (256). Burst firing in SLM interneurons suppresses spikes in pyramidal neurons evoked by stimulation of Schaffer collaterals (134), and, thereby allows selective activation of the pyramidal cells via the perforant pathway. PubMed:19126755

Appears in Networks:
Annotations
Uberon
hippocampus stratum lacunosum moleculare
Text Location
Review

act(a(HBP:"alpha-4 beta-2 nAChR")) decreases act(a(MESH:Interneurons)) View Subject | View Object

On the other hand, when alpha4beta2 nAChRs are activated, both SR and SLM interneurons are inhibited, resulting in disinhibition of dendritic areas innervated by both neuron types. PubMed:19126755

Appears in Networks:
Annotations
Uberon
hippocampus stratum lacunosum moleculare
Text Location
Review

Showing 4 of 4 edges

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.