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complex(GO:"Pick body")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Pick body
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 2

Tau Biochemistry v1.2.5

Tau Biochemistry Section of NESTOR

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 4

p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"Pick body") View Subject | View Object

Appears in Networks:

p(HGNC:PICALM) partOf complex(GO:"Pick body") View Subject | View Object

Appears in Networks:

path(MESH:"Pick Disease of the Brain") positiveCorrelation complex(GO:"Pick body") View Subject | View Object

Double immunostaining for PICALM and anti-phosphotau antibodies (AT8 and PHF1) showed a co-localisation of PICALM and phosphotau in Pick bodies of Pick disease PubMed:27260836

Appears in Networks:
Annotations
Disease Ontology (DO)
Pick's disease

p(HBP:"3R tau") positiveCorrelation complex(GO:"Pick body") View Subject | View Object

However, granule cells of the dentate gyrus mainly express 3R isoforms, which resist Tau aggregation in AD, but accumulate 3R aggregates in Pick's disease [14]. 3R Tau is a major Tau isoform in laser microdissected Pick bodies [15]. PubMed:26655600

Appears in Networks:
Annotations
Uberon
dentate gyrus granule cell layer
Disease Ontology (DO)
Pick's disease

Out-Edges 2

complex(GO:"Pick body") positiveCorrelation path(MESH:"Pick Disease of the Brain") View Subject | View Object

Double immunostaining for PICALM and anti-phosphotau antibodies (AT8 and PHF1) showed a co-localisation of PICALM and phosphotau in Pick bodies of Pick disease PubMed:27260836

Appears in Networks:
Annotations
Disease Ontology (DO)
Pick's disease

complex(GO:"Pick body") positiveCorrelation p(HBP:"3R tau") View Subject | View Object

However, granule cells of the dentate gyrus mainly express 3R isoforms, which resist Tau aggregation in AD, but accumulate 3R aggregates in Pick's disease [14]. 3R Tau is a major Tau isoform in laser microdissected Pick bodies [15]. PubMed:26655600

Appears in Networks:
Annotations
Uberon
dentate gyrus granule cell layer
Disease Ontology (DO)
Pick's disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.