1. Catalog
  2. Namespaces
  3. Uberon
  4. dentate gyrus granule cell layer

dentate gyrus granule cell layer

Name
dentate gyrus granule cell layer
Namespace Keyword
Anatomy
Namespace
Uberon
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/anatomy/anatomy-20170511.belanno

Sample Annotated Edges 5

a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) View Subject | View Object

E391-3610 mice (higher expressers) exhibit robust somatodendritic distribution of phospho- Ser 202/Thr 205 tau throughout the cortex, in hippocampal CA3 pyramidal neurons, CA1 apical dendrites and cell bodies and dentate granule cells. PubMed:22002427

Appears in Networks:
Annotations
Uberon
CA1 field of hippocampus
Uberon
CA3 field of hippocampus
Uberon
cerebral cortex
Uberon
dentate gyrus granule cell layer

a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 205)) View Subject | View Object

E391-3610 mice (higher expressers) exhibit robust somatodendritic distribution of phospho- Ser 202/Thr 205 tau throughout the cortex, in hippocampal CA3 pyramidal neurons, CA1 apical dendrites and cell bodies and dentate granule cells. PubMed:22002427

Appears in Networks:
Annotations
Uberon
CA1 field of hippocampus
Uberon
CA3 field of hippocampus
Uberon
cerebral cortex
Uberon
dentate gyrus granule cell layer

bp(GO:"neurofibrillary tangle assembly") negativeCorrelation p(HBP:"3R tau") View Subject | View Object

However, granule cells of the dentate gyrus mainly express 3R isoforms, which resist Tau aggregation in AD, but accumulate 3R aggregates in Pick's disease [14]. 3R Tau is a major Tau isoform in laser microdissected Pick bodies [15]. PubMed:26655600

Appears in Networks:
Annotations
Uberon
dentate gyrus granule cell layer
Disease Ontology (DO)
Alzheimer's disease

complex(GO:"Pick body") positiveCorrelation p(HBP:"3R tau") View Subject | View Object

However, granule cells of the dentate gyrus mainly express 3R isoforms, which resist Tau aggregation in AD, but accumulate 3R aggregates in Pick's disease [14]. 3R Tau is a major Tau isoform in laser microdissected Pick bodies [15]. PubMed:26655600

Appears in Networks:
Annotations
Uberon
dentate gyrus granule cell layer
Disease Ontology (DO)
Pick's disease

p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) View Subject | View Object

E391-3610 mice (higher expressers) exhibit robust somatodendritic distribution of phospho- Ser 202/Thr 205 tau throughout the cortex, in hippocampal CA3 pyramidal neurons, CA1 apical dendrites and cell bodies and dentate granule cells. PubMed:22002427

Appears in Networks:
Annotations
Uberon
CA1 field of hippocampus
Uberon
CA3 field of hippocampus
Uberon
cerebral cortex
Uberon
dentate gyrus granule cell layer

Showing 5 of 12 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.