1. Catalog
  2. Nodes
  3. p(HGNC:ARG1)

p(HGNC:ARG1)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
ARG1
Namespace
hgnc
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/hgnc-symbols.belns

Appears in Networks 2

Nuclear receptors as therapeutic targets for Alzheimer's disease. v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 9

act(p(HGNC:PPARD)) increases p(HGNC:ARG1) View Subject | View Object

Activation of PPAR-g or PPAR-d has been shown to induce Arg1 and IL-4 expression [105,106]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

act(p(HGNC:PPARG)) increases p(HGNC:ARG1) View Subject | View Object

Activation of PPAR-g or PPAR-d has been shown to induce Arg1 and IL-4 expression [105,106]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:heme) decreases p(HGNC:ARG1) View Subject | View Object

Likewise, heme and FeNTA treatment causes the induction of the M1 markers MHCII, CD86, CD14, TNFα, IL-6, and IL1β and a decrease in the M2 markers CD206, IL-10, and Arginase-1 (the last with FeNTA only) in M0 BMDMs (Figure 3A; supplemental Figures 5, 6A, and 7). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

a(CHEBI:heme) decreases p(HGNC:ARG1) View Subject | View Object

Importantly, 15 hours after heme injection, hepatic macrophages showed iron deposition (data not shown) and an increased expression of the M1 markers MHCII and CD86 and reduced levels of the M2 markers CD206 and Arginase-1 compared with nontreated mice. PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

a(CHEBI:heme) decreases p(HGNC:ARG1) View Subject | View Object

Likewise, splenic macrophages from heme-treated mice show increased expression of CD86 and reduced levels of CD206 and Arginase-1 (Figure 3D). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Spleen
MeSH
Anemia, Sickle Cell
Text Location
Results

p(HGNC:HPX) positiveCorrelation p(HGNC:ARG1) View Subject | View Object

In addition, Hx and DFO prevented the heme- and ironmediated induction of the M1 markers MHCII, CD86, CD14, and TNFα and the decrease of some M2 markers, such as CD206, IL-10, and Arginase-1 (the last for FeNTA only) in M0 BMDMs (Figure 6A; supplemental Figure 15A). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

path(MESH:"Pulmonary Embolism") positiveCorrelation p(HGNC:ARG1) View Subject | View Object

Humans with severe PE have increased arginase-1 and decreased plasma L-arginine concentrations.[14] PubMed:26337933

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:"Tricuspid Valve Insufficiency") positiveCorrelation p(HGNC:ARG1) View Subject | View Object

Table 3 shows a significant increase in the median value for the plasma biomarker of hemolysis, arginase-1 in patients with PE+TR+ by pairwise comparison using the Kruskal-Wallis test. PubMed:26337933

Appears in Networks:
Annotations
MeSH
Pulmonary Embolism
Text Location
Results

path(MESH:Hemolysis) positiveCorrelation p(HGNC:ARG1) View Subject | View Object

Table 3 shows a significant increase in the median value for the plasma biomarker of hemolysis, arginase-1 in patients with PE+TR+ by pairwise comparison using the Kruskal-Wallis test. PubMed:26337933

Appears in Networks:
Annotations
MeSH
Pulmonary Embolism
Text Location
Results

Out-Edges 4

p(HGNC:ARG1) positiveCorrelation path(MESH:"Pulmonary Embolism") View Subject | View Object

Humans with severe PE have increased arginase-1 and decreased plasma L-arginine concentrations.[14] PubMed:26337933

Appears in Networks:
Annotations
Text Location
Introduction

p(HGNC:ARG1) positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Table 3 shows a significant increase in the median value for the plasma biomarker of hemolysis, arginase-1 in patients with PE+TR+ by pairwise comparison using the Kruskal-Wallis test. PubMed:26337933

Appears in Networks:
Annotations
MeSH
Pulmonary Embolism
Text Location
Results

p(HGNC:ARG1) positiveCorrelation path(MESH:"Tricuspid Valve Insufficiency") View Subject | View Object

Table 3 shows a significant increase in the median value for the plasma biomarker of hemolysis, arginase-1 in patients with PE+TR+ by pairwise comparison using the Kruskal-Wallis test. PubMed:26337933

Appears in Networks:
Annotations
MeSH
Pulmonary Embolism
Text Location
Results

p(HGNC:ARG1) positiveCorrelation p(HGNC:HPX) View Subject | View Object

In addition, Hx and DFO prevented the heme- and ironmediated induction of the M1 markers MHCII, CD86, CD14, and TNFα and the decrease of some M2 markers, such as CD206, IL-10, and Arginase-1 (the last for FeNTA only) in M0 BMDMs (Figure 6A; supplemental Figure 15A). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.