1. Catalog
  2. Nodes
  3. p(HGNC:PPARG)

p(HGNC:PPARG)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
PPARG
Namespace
hgnc
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/hgnc-symbols.belns

Appears in Networks 2

Nuclear receptors as therapeutic targets for Alzheimer's disease. v1.0.0

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

In-Edges 7

a(CHEBI:pioglitazone) increases act(p(HGNC:PPARG)) View Subject | View Object

The synthetic TZD PPAR-g agonists are widely prescribed for the treatment of type 2 diabetes mellitus, and have also been shown to be efficacious in a number of CNS disease models [21]. Currently, two TZD agonists, Actos (pioglitazone) and Avandia (rosiglitazone), are FDA approved for the treatment of diabetes. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) View Subject | View Object

The synthetic TZD PPAR-g agonists are widely prescribed for the treatment of type 2 diabetes mellitus, and have also been shown to be efficacious in a number of CNS disease models [21]. Currently, two TZD agonists, Actos (pioglitazone) and Avandia (rosiglitazone), are FDA approved for the treatment of diabetes. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) View Subject | View Object

Pedersen and Flynn examined the effects of rosiglitazone and found that activation of PPAR-g ameliorated behavioral deficits in the Tg2576 AD mouse model. However, these animals displayed no changes in plaque pathology, but had reduced brain Ab42 levels. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

bp(GO:"lipid storage") association p(HGNC:PPARG) View Subject | View Object

PPAR-g is involved in lipid storage, insulin sensitivity and energy metabolism and has been shown to promote adipocyte differentiation [21]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

bp(GO:"response to insulin") association p(HGNC:PPARG) View Subject | View Object

PPAR-g is involved in lipid storage, insulin sensitivity and energy metabolism and has been shown to promote adipocyte differentiation [21]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

bp(MESH:"Energy Metabolism") association p(HGNC:PPARG) View Subject | View Object

PPAR-g is involved in lipid storage, insulin sensitivity and energy metabolism and has been shown to promote adipocyte differentiation [21]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) View Subject | View Object

Rosiglitazone, a highaffinity agonist for PPARγ, can clear Aβ by activating microglia and promoting its phagocytosis via increasing the levels of CD36, a receptor expressed in it (Escribano et al. 2010) PubMed:29626319

Appears in Networks:

Out-Edges 13

act(p(HGNC:PPARG)) increases path(MESH:"Alzheimer Disease") View Subject | View Object

In the past decade, drugs targeting the NRs, peroxisome proliferator-activated receptor g (PPARg) and liver X receptor (LXR) have shown to ameliorate pathogenesis in animal models of AD. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

act(p(HGNC:PPARG)) increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

Recently, they have been shown to promote the degradation of the Ab peptides in the brain by activating genes responsible for reverse cholesterol transport [13]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

act(p(HGNC:PPARG)) increases bp(GO:"reverse cholesterol transport") View Subject | View Object

Recently, they have been shown to promote the degradation of the Ab peptides in the brain by activating genes responsible for reverse cholesterol transport [13]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

act(p(HGNC:PPARG)) decreases bp(GO:"microglial cell activation involved in immune response") View Subject | View Object

Activation of these receptors has been shown to suppress microglial-mediated inflammatory responses both in vitro and in vivo. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

p(HGNC:PPARG) association bp(MESH:"Energy Metabolism") View Subject | View Object

PPAR-g is involved in lipid storage, insulin sensitivity and energy metabolism and has been shown to promote adipocyte differentiation [21]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

p(HGNC:PPARG) increases bp(GO:"fat cell differentiation") View Subject | View Object

PPAR-g is involved in lipid storage, insulin sensitivity and energy metabolism and has been shown to promote adipocyte differentiation [21]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

p(HGNC:PPARG) association bp(GO:"response to insulin") View Subject | View Object

PPAR-g is involved in lipid storage, insulin sensitivity and energy metabolism and has been shown to promote adipocyte differentiation [21]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

p(HGNC:PPARG) association bp(GO:"lipid storage") View Subject | View Object

PPAR-g is involved in lipid storage, insulin sensitivity and energy metabolism and has been shown to promote adipocyte differentiation [21]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

p(HGNC:PPARG) increases p(HGNC:APOE) View Subject | View Object

Numerous studies have shown that both PPAR-g and LXRs induce the expression of ApoE and ABCA1 and it is through the expression of these proteins that they exert their effects on amyloid pathology. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

p(HGNC:PPARG) increases p(HGNC:ABCA1) View Subject | View Object

Numerous studies have shown that both PPAR-g and LXRs induce the expression of ApoE and ABCA1 and it is through the expression of these proteins that they exert their effects on amyloid pathology. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

p(HGNC:PPARG) increases p(HGNC:NR1H3) View Subject | View Object

Additionally, PPAR-g can also induce the expression of LXRa creating a metabolically linked cycle. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

act(p(HGNC:PPARG)) increases p(HGNC:ARG1) View Subject | View Object

Activation of PPAR-g or PPAR-d has been shown to induce Arg1 and IL-4 expression [105,106]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

act(p(HGNC:PPARG)) increases p(HGNC:IL4) View Subject | View Object

Activation of PPAR-g or PPAR-d has been shown to induce Arg1 and IL-4 expression [105,106]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.