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a(CHEBI:probenecid)

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Entity

Name
probenecid
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

The role of inflammasome in Alzheimer’s disease v1.0.3

In-Edges 0

Out-Edges 6

a(CHEBI:probenecid) decreases p(HGNC:PANX1) View Subject | View Object

Probenecid, an inhibitor of pannexin 1, has been shown to significantly inhibit the expression and activation of the NLRP2 inflammasome, and the maturation of bothIL-1β and IL-18 in human astrocytes induced by ATP (Minkiewicz et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Confidence
Medium

a(CHEBI:probenecid) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) View Subject | View Object

Probenecid, an inhibitor of pannexin 1, has been shown to significantly inhibit the expression and activation of the NLRP2 inflammasome, and the maturation of bothIL-1β and IL-18 in human astrocytes induced by ATP (Minkiewicz et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Confidence
Medium

a(CHEBI:probenecid) decreases p(HGNC:IL1B) View Subject | View Object

Probenecid, an inhibitor of pannexin 1, has been shown to significantly inhibit the expression and activation of the NLRP2 inflammasome, and the maturation of bothIL-1β and IL-18 in human astrocytes induced by ATP (Minkiewicz et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

a(CHEBI:probenecid) decreases p(HGNC:IL18) View Subject | View Object

Probenecid, an inhibitor of pannexin 1, has been shown to significantly inhibit the expression and activation of the NLRP2 inflammasome, and the maturation of bothIL-1β and IL-18 in human astrocytes induced by ATP (Minkiewicz et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte
Confidence
Medium
NeuroMMSigDB
Interleukin signaling subgraph

a(CHEBI:probenecid) decreases act(complex(GO:"NLRP1 inflammasome complex")) View Subject | View Object

Probenecid has also been demonstrated to reduce the activation of the NLRP1 inflammasome, and improve the learning performance in age-related cognitive decline (Mawhinney et al., 2011) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:probenecid) increases bp(GO:learning) View Subject | View Object

Probenecid has also been demonstrated to reduce the activation of the NLRP1 inflammasome, and improve the learning performance in age-related cognitive decline (Mawhinney et al., 2011) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.