complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1))

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PubMed:28019679

Recently, Kaushal et al. described the involvement of NLRP1 inflammasome activation in neurons. In these experiments, serum deprivation induced NLRP1-dependent caspase-1 activity and ASC speck formation, which resulted in caspase-6 activation and an increase in the Ab42/total Ab ratio (11)

Related Edges 2

• act(complex(GO:"NLRP1 inflammasome complex")) increases act(p(HGNC:CASP6))
• act(complex(GO:"NLRP1 inflammasome complex")) increases a(CHEBI:"amyloid-beta polypeptide 42")

Confidence

High

NeuroMMSigDB

Caspase subgraph

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