act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL1B))

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PubMed:24561250

Spinal cord injury causes IL-18 and IL-1β release from neuronal cells through the activation of the NLRP1 inflammasome, composed of receptor NLRP1, adaptor protein ASC, caspase-1, caspase-11 and X-linked inhibitor of apoptosis protein (de Rivero Vaccari et al., 2008)

Related Edges 4

• act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL18))
• path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex"))
• path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL18))
• path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL1B))

Confidence

High

MeSH

Neurons

NeuroMMSigDB

Interleukin signaling subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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