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Inert and seed-competent tau monomers suggest structural origins of aggregation 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-03-15 15:44:08.452021
Authors
Esther Wollert
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
8
Number Edges
11
Number Components
1
Network Density
0.196428571428571
Average Degree
1.375
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Tau in physiology and pathology v1.0.0 50%
Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0 50%
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies v1.0.0 50%
Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0 50%
Tau oligomers and tau toxicity in neurodegenerative disease v1.0.0 50%
Tau Modifications v1.9.5 50%
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation v1.0.0 50%
Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems v1.0.1 38%
Caenorhabditis elegans models of tauopathy v1.0.0 38%
Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes v1.0.0 38%

Sample Edges

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, var("?")) View Subject | View Object

complex(p(HGNC:MAPT), p(HGNC:MAPT)) hasComponent p(HGNC:MAPT) View Subject | View Object

a(CHEBI:heparin) increases p(HGNC:MAPT, var("?")) View Subject | View Object

After 15 min of heparin exposure, we detected low but significant amounts of seed-compe- tent monomer, and much fewer larger assemblies (Figure 6A). PubMed:29988016

a(CHEBI:heparin) increases a(HBP:"Tau aggregates") View Subject | View Object

After 15 min of heparin exposure, we detected low but significant amounts of seed-compe- tent monomer, and much fewer larger assemblies (Figure 6A). PubMed:29988016

a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Tau from control brain purified in the monomer fraction (Figure 8A), while tau from AD brain distributed across multiple fractions, corresponding to monomer and larger assem- blies (Figure 8B). PubMed:29988016

Annotations
MeSH
Brain

Sample Nodes

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON

p(HGNC:MAPT)

In-Edges: 477 | Out-Edges: 480 | Classes: 11 | Children: 27 | Explore Neighborhood | Download JSON

p(HGNC:MAPT, var("?"))

In-Edges: 9 | Out-Edges: 10 | Explore Neighborhood | Download JSON

a(HBP:"Tau aggregates")

In-Edges: 224 | Out-Edges: 71 | Children: 3 | Explore Neighborhood | Download JSON

a(CHEBI:heparin)

In-Edges: 4 | Out-Edges: 11 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.