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Appears in Networks 3

In-Edges 3

a(HBP:"Tau oligomers") increases sec(p(HGNC:CYCS)) View Subject | View Object

Suggestively, as tau oligomers concentrate at the mitochondrial membrane, cytochrome C is released, leading to caspase-9 activation via a complex with apoptotic-peptidase activating- factor-1 (Apaf-1; Li et al., 1997) PubMed:28420982

p(HBP:"Tau oligomers", var("p.Lys280del")) increases sec(p(HGNC:CYCS)) View Subject | View Object

To address this question, we first applied the oligomers directly after the purification of the protein eluting from the Butyl FF 16/ 10 column (without buffer exchange; 1, 5, and 10 mM) to SHSY5Y cells and observed a variety of toxic effects, including pronounced reduction in the cell viability (by MTT assay, Fig. 3A), increase in apoptotic cells (by Hoechst staining, Supplementary Fig. 4A), loss of mitochondrial membrane potential (by JC1 assay, Supplementary Fig. 4B), caspase 3/7 activation (Supplementary Fig. 4C-D), and cytochrome-c release (Supplementary Fig. 4), within 5 hours of incubation. PubMed:28528849

Out-Edges 2

tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases act(complex(GO:apoptosome)) View Subject | View Object

Indeed, inflammasomes (which induce pyroptosis through caspase 1 or caspase 11 activation) and apoptosomes (which activate caspase 9 in response to cytochrome c release from mitochondria) are two mechanisms by which compromised cells are eliminated. PubMed:23702978

tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases complex(p(HGNC:APAF1), p(HGNC:CYCS)) View Subject | View Object

Indeed, the binding of cytochrome c that has been released from mitochondria to apoptotic protease-activating factor 1 (APAF1) and the subsequent assembly of the apoptosome only occurs when subphysiological K+ concentrations are reached in compromised cells77,78. PubMed:23702978

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.