1. Catalog
  2. Networks
  3. Alpha-synuclein oligomers: a new hope v1.0.0

Alpha-synuclein oligomers: a new hope 1.0.0

Compilation Biogrammar
Explore Query

Provenance

Upload
charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:21:28.314755
Authors
Esther Wollert
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved
Number Nodes
48
Number Edges
64
Number Components
2
Network Density
0.0283687943262411
Average Degree
1.33333333333333
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Structural and functional properties of prefibrillar α-synuclein oligomers v1.0.0 54%
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0 33%
Tau Modifications v1.9.5 25%
The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0 25%
Alzheimer’s disease and the autophagic-lysosomal system v1.0.0 21%
In Vivo and In Vitro Characterization of Antalarmin, a Nonpeptide Corticotropin-Releasing Hormone (CRH) Receptor Antagonist: Suppression of Pituitary ACTH Release and Peripheral Inflammation v1.0.0 20%
The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0 17%
Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection v1.0.0 17%
mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0 15%
The Biology of Proteostasis in Aging and Disease v1.0.0 15%

Sample Edges

p(HGNC:PRKN) hasVariant p(HGNC:PRKN, var("?")) View Subject | View Object

p(HGNC:SNCA) hasVariant p(HGNC:SNCA, var("p.Ala30Pro")) View Subject | View Object

p(HGNC:SNCA) hasVariant p(HGNC:SNCA, var("p.Ala53Thr")) View Subject | View Object

a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00016) View Subject | View Object

Epigallocatechin-3-gallate (EGCG), a small molecule that been shown to inhibit the aggregation of several amyloidogenic proteins such as a-syn, amyloid-beta and huntingtin [9, 37, 38, 105] binds to unfolded native amyloid-beta and a-syn and promotes the formation of nontoxic oligomers that do not convert into amyloid fibrils [37]. PubMed:28803412

Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum

a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00018) View Subject | View Object

Epigallocatechin-3-gallate (EGCG), a small molecule that been shown to inhibit the aggregation of several amyloidogenic proteins such as a-syn, amyloid-beta and huntingtin [9, 37, 38, 105] binds to unfolded native amyloid-beta and a-syn and promotes the formation of nontoxic oligomers that do not convert into amyloid fibrils [37]. PubMed:28803412

Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum

Sample Nodes

a(HBP:HBP00018)

In-Edges: 35 | Out-Edges: 8 | Explore Neighborhood | Download JSON

bp(GO:"inflammatory response")

In-Edges: 55 | Out-Edges: 24 | Explore Neighborhood | Download JSON

path(MESH:"Parkinson Disease")

In-Edges: 68 | Out-Edges: 53 | Explore Neighborhood | Download JSON

a(CHEBI:"calcium(2+)")

In-Edges: 56 | Out-Edges: 30 | Explore Neighborhood | Download JSON

bp(GO:"microglial cell activation")

In-Edges: 18 | Out-Edges: 8 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.