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Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine 1.0.1

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:16:02.959802
Authors
Esther Wollert
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
17
Number Edges
21
Number Components
4
Network Density
0.0772058823529412
Average Degree
1.23529411764706
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System v1.0.0 71%
albuquerque2009 v1.0.0 59%
Alzheimer's Disease: Targeting the Cholinergic System v1.0.0 35%
Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0 35%
Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1 29%
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0 29%
Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0 29%
Chaperoning α7 neuronal nicotinic acetylcholine receptors v1.0.0 24%
Naturally-expressed nicotinic acetylcholine receptor subtypes v1.0.0 24%
NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0 18%

Sample Edges

tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") View Subject | View Object

While nAChR activity causes depolarization, the divalent cation permeability plays an impor- tant physiological role by supplying ionic signals, including calcium (Bertrand, Galzi, Devillers-Thiery, Bertrand, & Changeux, 1993b; Dani & Bertrand, 2007; Decker & Dani, 1990; Gray, Rajan, Radcliffe, Yakehiro, & Dani, 1996; McGehee, Heath, Gelber, Devay, & Role, 1995; Vernino et al., 1992). PubMed:26472524

a(CHEBI:"calcium(2+)") regulates act(p(FPLX:CHRN)) View Subject | View Object

Although calcium modulation can act intracellularly, nAChRs also are allosterically modulated by extracellular calcium, leading to dramatic changes in the channel opening probability (Amador & Dani, 1995; Mulle, Lena, & Changeux, 1992; Vernino et al., 1992). PubMed:26472524

Annotations
MeSH
Extracellular Space

a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) View Subject | View Object

Those that contain β 2 ( β 2 * ) commonly have high affinity for nicotine, desensitize to low agonist con- centrations, have relatively slow kinetics, and do not bind α -bungarotoxin. PubMed:26472524

tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") View Subject | View Object

While nAChR activity causes depolarization, the divalent cation permeability plays an impor- tant physiological role by supplying ionic signals, including calcium (Bertrand, Galzi, Devillers-Thiery, Bertrand, & Changeux, 1993b; Dani & Bertrand, 2007; Decker & Dani, 1990; Gray, Rajan, Radcliffe, Yakehiro, & Dani, 1996; McGehee, Heath, Gelber, Devay, & Role, 1995; Vernino et al., 1992). PubMed:26472524

bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") View Subject | View Object

Simultaneously, activity of postsynaptic (and somatic) α 4 β 2 * nAChRs depolarizes DA neurons leading to enhanced action potential firing (Zhang et al., 2009). PubMed:26472524

Annotations
Cell Ontology (CL)
dopaminergic neuron
MeSH
Post-Synaptic Density

Sample Nodes

a(CHEBI:"calcium(2+)")

In-Edges: 56 | Out-Edges: 30 | Explore Neighborhood | Download JSON

bp(GO:"long-term synaptic potentiation")

In-Edges: 39 | Out-Edges: 20 | Explore Neighborhood | Download JSON

a(CHEBI:"glutamate(2-)")

In-Edges: 14 | Out-Edges: 5 | Explore Neighborhood | Download JSON

a(CHEBI:nicotine)

In-Edges: 70 | Out-Edges: 181 | Explore Neighborhood | Download JSON

bp(GO:"depolarization of postsynaptic membrane")

In-Edges: 3 | Out-Edges: 5 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.