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a(CHEBI:"L-arginine")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
L-arginine
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 2

p(HGNC:HBB) decreases a(CHEBI:"L-arginine") View Subject | View Object

Release of hemoglobin (and ultimately heme), and arginase-1 into the plasma results in binding of nitric oxide and also reduction in L-arginine, respectively, causing a relative reduction in vasodilatory effect.[14,29] PubMed:26337933

Appears in Networks:
Annotations
Cell Ontology (CL)
leukocyte
MeSH
Plasma
MeSH
Pulmonary Embolism
Text Location
Discussion

path(MESH:"Pulmonary Embolism") negativeCorrelation a(CHEBI:"L-arginine") View Subject | View Object

Humans with severe PE have increased arginase-1 and decreased plasma L-arginine concentrations.[14] PubMed:26337933

Appears in Networks:
Annotations
Text Location
Introduction

Out-Edges 2

a(CHEBI:"L-arginine") decreases bp(MESH:"Platelet Aggregation") View Subject | View Object

Platelet deposition and adhesion at sites of subintimal injury are increased by free haemoglobin or inhibition of NO production; this effect can be prevented by infusions of L-arginine, the precursor of NO (Olsen et al, 1996). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(CHEBI:"L-arginine") negativeCorrelation path(MESH:"Pulmonary Embolism") View Subject | View Object

Humans with severe PE have increased arginase-1 and decreased plasma L-arginine concentrations.[14] PubMed:26337933

Appears in Networks:
Annotations
Text Location
Introduction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.