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complex(a(CHEBI:heme), p(INTERPRO:"NEAT domain"))

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Components

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 0

Out-Edges 5

complex(a(CHEBI:heme), p(INTERPRO:"NEAT domain")) hasComponent a(CHEBI:heme) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:heme), p(INTERPRO:"NEAT domain")) hasComponent p(INTERPRO:"NEAT domain") View Subject | View Object

Appears in Networks:

complex(a(CHEBI:heme), p(INTERPRO:"NEAT domain")) decreases act(a(CHEBI:Peroxidase)) View Subject | View Object

At the same time, heme bound to NEAT does not catalyze the peroxidase reaction due to inability to interact with H2O2. PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Results

complex(a(CHEBI:heme), p(INTERPRO:"NEAT domain")) increases a(CHEBI:"nitric oxide") View Subject | View Object

This ability of NEAT can decrease the level of NO scavenging and oxidative stress in SCD. PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Discussion

complex(a(CHEBI:heme), p(INTERPRO:"NEAT domain")) decreases bp(MESH:"Oxidative Stress") View Subject | View Object

This ability of NEAT can decrease the level of NO scavenging and oxidative stress in SCD. PubMed:28088643

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Macrophages
MeSH
Anemia, Sickle Cell
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.