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path(MESH:Hematoma)

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Entity

Name
Hematoma
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 16

a(CHEBI:"desferrioxamine B") negativeCorrelation path(MESH:Hematoma) View Subject | View Object

In combination, these finding may underlie our previous results showing that DFX slows hematoma resolution after ICH in aged rats 12. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

a(HM:erythrophagocytosis) positiveCorrelation path(MESH:Hematoma) View Subject | View Object

Erythrophagocytosis was observed in the hematoma edge at day-3 (Fig. 3A), and hemosiderin deposition was identifiable in the hematoma edge at day-7 (Fig. 3A). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

a(MESH:"Complement Membrane Attack Complex") positiveCorrelation path(MESH:Hematoma) View Subject | View Object

In this present study, MAC contents in the clot gradually increased with a marked accumulation at day-3 (53.5 ± 8.2 vs. 11.0 ± 3.9 ng/g at 4 hour, p<0.01, Fig. 2C) and stayed at high levels at day 7. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

a(MESH:Hemosiderin) positiveCorrelation path(MESH:Hematoma) View Subject | View Object

Erythrophagocytosis was observed in the hematoma edge at day-3 (Fig. 3A), and hemosiderin deposition was identifiable in the hematoma edge at day-7 (Fig. 3A). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

bp(HM:"Atheromatous lesions") positiveCorrelation path(MESH:Hematoma) View Subject | View Object

Hematomas occur in atheromatous lesions and plaque material contains lipid oxidation products including lipid hydroperoxide22 which can mediate not only the oxidation of hemoglobin but might also lyse intact red cells.23 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis
Text Location
Results

bp(HM:"Atheromatous lesions") positiveCorrelation path(MESH:Hematoma) View Subject | View Object

Atheromatous lesions are prone to disruption leading to hematoma or hemorrhage. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Discussion

bp(MESH:"Erythrocyte Indices") negativeCorrelation path(MESH:Hematoma) View Subject | View Object

We found that diameter of RBC decreased gradually in the hematoma edge and hematoma center (e.g. day-3 at hematoma edge: 2.71 ± 0.38μm vs. 3.89 ± 0.35μm at 4 hours, p<0.01; hematoma center: 2.61 ± 0.29 μm vs. 3.75 ± 0.25μm at 4 hours, p<0.01. Fig. 1). PubMed:27125525

Appears in Networks:
Annotations
Text Location
Results

bp(MESH:"Erythrocyte Indices") negativeCorrelation path(MESH:Hematoma) View Subject | View Object

The diameter of RBCs within the hematoma decreased with time after ICH. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Discussion

bp(MESH:Phagocytosis) negativeCorrelation path(MESH:Hematoma) View Subject | View Object

The hematoma clearance may be via red blood cell (RBC) lysis or phagocytosis. PubMed:27125525

Appears in Networks:
Annotations
Text Location
Introduction

p(HGNC:HBB) negativeCorrelation path(MESH:Hematoma) View Subject | View Object

The level of hemoglobin declined gradually over the time after the onset of ICH with a significant reduction at day 3. The contents of hemoglobin in the clot were 26.2 ± 5.2 mg/g at 4 hours, but were reduced to 13.9 ± 0.9 mg/g at day-3 (Fig. 2B, p<0.01). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

p(HGNC:HBB) negativeCorrelation path(MESH:Hematoma) View Subject | View Object

We found that hemoglobin contents in hematoma were significantly higher in the DFX treated group compare to the vehicle-treated group (15.9 ± 1.8 vs. 11.8 ± 0.8 mg/g, p<0.05, Fig. 5A). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

p(HGNC:CD163) positiveCorrelation path(MESH:Hematoma) View Subject | View Object

CD163 and HO-1 positive cells infiltrated into the hematoma from edge to center after ICH (Figs. 4A & 4B). A significant increase of CD163 cells was found at day 3. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

p(HGNC:CD47) negativeCorrelation path(MESH:Hematoma) View Subject | View Object

The current study examined the natural time course of CD47 expression in the hematoma in a swine ICH model and found that CD47 levels in the clot decrease with time. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Discussion

p(HGNC:CD47) negativeCorrelation path(MESH:Hematoma) View Subject | View Object

Our recent study showed that depleting CD47 in RBCs resulted in faster hematoma clearance with microglia/ macrophages being less likely to phagocytize RBCs with CD47 than CD47-deficient RBC 7. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

p(HGNC:HMOX1) positiveCorrelation path(MESH:Hematoma) View Subject | View Object

HO-1 protein levels in the hematoma also increased at day-3 (HO-1/GAPDH: 0.65 ± 0.08 at day-3 vs. 0.04 ± 0.01 at 4 hour, p<0.01). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

path(MESH:"Cerebral Hemorrhage") positiveCorrelation path(MESH:Hematoma) View Subject | View Object

Hematoma resolution occurs in the days after intracerebral hemorrhage (ICH). PubMed:27125525

Appears in Networks:
Annotations
Text Location
Introduction

Out-Edges 16

path(MESH:Hematoma) positiveCorrelation a(MESH:"Complement Membrane Attack Complex") View Subject | View Object

In this present study, MAC contents in the clot gradually increased with a marked accumulation at day-3 (53.5 ± 8.2 vs. 11.0 ± 3.9 ng/g at 4 hour, p<0.01, Fig. 2C) and stayed at high levels at day 7. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

path(MESH:Hematoma) positiveCorrelation a(HM:erythrophagocytosis) View Subject | View Object

Erythrophagocytosis was observed in the hematoma edge at day-3 (Fig. 3A), and hemosiderin deposition was identifiable in the hematoma edge at day-7 (Fig. 3A). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

path(MESH:Hematoma) positiveCorrelation a(MESH:Hemosiderin) View Subject | View Object

Erythrophagocytosis was observed in the hematoma edge at day-3 (Fig. 3A), and hemosiderin deposition was identifiable in the hematoma edge at day-7 (Fig. 3A). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

path(MESH:Hematoma) positiveCorrelation bp(HM:"Atheromatous lesions") View Subject | View Object

Hematomas occur in atheromatous lesions and plaque material contains lipid oxidation products including lipid hydroperoxide22 which can mediate not only the oxidation of hemoglobin but might also lyse intact red cells.23 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis
Text Location
Results

path(MESH:Hematoma) positiveCorrelation bp(HM:"Atheromatous lesions") View Subject | View Object

Atheromatous lesions are prone to disruption leading to hematoma or hemorrhage. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Discussion

path(MESH:Hematoma) positiveCorrelation path(MESH:"Cerebral Hemorrhage") View Subject | View Object

Hematoma resolution occurs in the days after intracerebral hemorrhage (ICH). PubMed:27125525

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Hematoma) negativeCorrelation bp(MESH:Phagocytosis) View Subject | View Object

The hematoma clearance may be via red blood cell (RBC) lysis or phagocytosis. PubMed:27125525

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Hematoma) negativeCorrelation bp(MESH:"Erythrocyte Indices") View Subject | View Object

We found that diameter of RBC decreased gradually in the hematoma edge and hematoma center (e.g. day-3 at hematoma edge: 2.71 ± 0.38μm vs. 3.89 ± 0.35μm at 4 hours, p<0.01; hematoma center: 2.61 ± 0.29 μm vs. 3.75 ± 0.25μm at 4 hours, p<0.01. Fig. 1). PubMed:27125525

Appears in Networks:
Annotations
Text Location
Results

path(MESH:Hematoma) negativeCorrelation bp(MESH:"Erythrocyte Indices") View Subject | View Object

The diameter of RBCs within the hematoma decreased with time after ICH. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Discussion

path(MESH:Hematoma) negativeCorrelation p(HGNC:HBB) View Subject | View Object

The level of hemoglobin declined gradually over the time after the onset of ICH with a significant reduction at day 3. The contents of hemoglobin in the clot were 26.2 ± 5.2 mg/g at 4 hours, but were reduced to 13.9 ± 0.9 mg/g at day-3 (Fig. 2B, p<0.01). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

path(MESH:Hematoma) negativeCorrelation p(HGNC:HBB) View Subject | View Object

We found that hemoglobin contents in hematoma were significantly higher in the DFX treated group compare to the vehicle-treated group (15.9 ± 1.8 vs. 11.8 ± 0.8 mg/g, p<0.05, Fig. 5A). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

path(MESH:Hematoma) positiveCorrelation p(HGNC:CD163) View Subject | View Object

CD163 and HO-1 positive cells infiltrated into the hematoma from edge to center after ICH (Figs. 4A & 4B). A significant increase of CD163 cells was found at day 3. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

path(MESH:Hematoma) positiveCorrelation p(HGNC:HMOX1) View Subject | View Object

HO-1 protein levels in the hematoma also increased at day-3 (HO-1/GAPDH: 0.65 ± 0.08 at day-3 vs. 0.04 ± 0.01 at 4 hour, p<0.01). PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

path(MESH:Hematoma) negativeCorrelation p(HGNC:CD47) View Subject | View Object

The current study examined the natural time course of CD47 expression in the hematoma in a swine ICH model and found that CD47 levels in the clot decrease with time. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Discussion

path(MESH:Hematoma) negativeCorrelation p(HGNC:CD47) View Subject | View Object

Our recent study showed that depleting CD47 in RBCs resulted in faster hematoma clearance with microglia/ macrophages being less likely to phagocytize RBCs with CD47 than CD47-deficient RBC 7. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

path(MESH:Hematoma) negativeCorrelation a(CHEBI:"desferrioxamine B") View Subject | View Object

In combination, these finding may underlie our previous results showing that DFX slows hematoma resolution after ICH in aged rats 12. PubMed:27125525

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Cerebral Hemorrhage
Text Location
Discussion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.