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path(HM:"Endothelial dysfunction")

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Entity

Name
Endothelial dysfunction
Namespace
HM
Namespace Version
None
Pattern
.*

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 13

a(CHEBI:"iron trichloride") negativeCorrelation path(HM:"Endothelial dysfunction") View Subject | View Object

To investigate the direct effects of FeCl3 on aortic endothelium, FeCl3 was perfused through isolated aorta independently of flowing blood. Strikingly no endothelial denudation or collagen exposure was evident following prolonged exposure to FeCl3 (6%) (Fig. 1C). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Aorta
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation path(HM:"Endothelial dysfunction") View Subject | View Object

Subsequent perfusion of anticoagulated whole blood through FeCl3-pretreated vessels was associated with an increase in leukocyte and platelet adhesion to the vessel wall (Fig. 1E and supplemental Video 2); however, relative to untreated aorta (Fig. 1F and supplemental Video 3) and treatment in the presence of flowing blood (Fig. 1D and supplemental Video 1), thrombus formation was not observed. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Blood
Text Location
Introduction

a(CHEBI:"iron trichloride") positiveCorrelation path(HM:"Endothelial dysfunction") View Subject | View Object

In contrast, selectively removing RBCs prevented endothelial denudation and collagen exposure, resulting in a relatively mild perturbation of endothelial function similar to that observed with FeCl3 alone (data not shown). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Blood
Text Location
Introduction

a(CHEBI:"oxidised LDL") increases path(HM:"Endothelial dysfunction") View Subject | View Object

Oxidized LP(ox- LP) then induces toxic effects in endothelial cells [6]. PubMed:26475040

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Abstract

a(CHEBI:heme) increases path(HM:"Endothelial dysfunction") View Subject | View Object

Many studies have explored basic mechanisms of Hb or heme triggered endothelial damage and have suggested that oxidative reactions of Hb generate multiple toxic species such as free heme that is released from ferric Hb, iron, free radicals, and globin aggregation products [15],[16],[17],[18],[19],[20],[21],[22],[23],[24],[25]. PubMed:26475040

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Abstract

a(HM:"Atheroma lipid") positiveCorrelation path(HM:"Endothelial dysfunction") View Subject | View Object

As shown in Fig 3B, lipids from atherosclerotic lesions were cytotoxic to endothelium, an effect strikingly enhanced when lipids were pre-oxidized by exposure to heme. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

p(HGNC:HBB) increases path(HM:"Endothelial dysfunction") View Subject | View Object

Many studies have explored basic mechanisms of Hb or heme triggered endothelial damage and have suggested that oxidative reactions of Hb generate multiple toxic species such as free heme that is released from ferric Hb, iron, free radicals, and globin aggregation products [15],[16],[17],[18],[19],[20],[21],[22],[23],[24],[25]. PubMed:26475040

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Abstract

p(HGNC:HBB) increases path(HM:"Endothelial dysfunction") View Subject | View Object

Compared to wild-type (WT) mice, mice with 117 endothelial dysfunction have an increased vasoconstrictor response to infusion of 118 cell-free hemoglobin (25). PubMed:28314763

Appears in Networks:
Annotations
Text Location
Introduction

complex(a(CHEBI:"iron trichloride"), a(CHEBI:methemoglobin)) positiveCorrelation path(HM:"Endothelial dysfunction") View Subject | View Object

Topical treatment with 6% FeCl3 with hemin (1mM) perfusions caused no greater endothelial injury than FeCl3 or hemin (1 mM) alone (data not shown), whereas FeCl3 in the presence of low concentrations of metHb (0.38 mg/ml) induced extensive vascular injury similar to that observed with FeCl3 in the presence of whole blood (Figs. 4 and 1D, respectively). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

complex(a(CHEBI:"iron trichloride"), a(CHEBI:methemoglobin)) positiveCorrelation path(HM:"Endothelial dysfunction") View Subject | View Object

Third, reintroduction of washed RBCs or purified metHb in the presence of FeCl3 led to a similar level of vascular injury as observed with whole blood, whereas isolated RBC membranes and heme, even in the presence of FeCl3, produced relatively mild injury. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Discussion

p(HGNC:HPX) decreases path(HM:"Endothelial dysfunction") View Subject | View Object

We have found that atheroma lipids when oxidized by heme are highly cytotoxic to human endothelial cells, and hemopexin reduced this cytotoxicity. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis
Text Location
Discussion

path(MESH:Hyperlipidemias) increases path(HM:"Endothelial dysfunction") View Subject | View Object

Endothelial dysfunction, a condition associated with reduced bioavailability of 282 vascular NO, occurs in humans and mice with hyperlipidemia (16). PubMed:28314763

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Thrombosis) positiveCorrelation path(HM:"Endothelial dysfunction") View Subject | View Object

The triad consists of hypercoagulability, blood stasis and endothelial injury/dysfunction, which are useful concepts for understanding thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Text Location
Review

Out-Edges 7

path(HM:"Endothelial dysfunction") negativeCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

To investigate the direct effects of FeCl3 on aortic endothelium, FeCl3 was perfused through isolated aorta independently of flowing blood. Strikingly no endothelial denudation or collagen exposure was evident following prolonged exposure to FeCl3 (6%) (Fig. 1C). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Aorta
Text Location
Introduction

path(HM:"Endothelial dysfunction") positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

Subsequent perfusion of anticoagulated whole blood through FeCl3-pretreated vessels was associated with an increase in leukocyte and platelet adhesion to the vessel wall (Fig. 1E and supplemental Video 2); however, relative to untreated aorta (Fig. 1F and supplemental Video 3) and treatment in the presence of flowing blood (Fig. 1D and supplemental Video 1), thrombus formation was not observed. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Blood
Text Location
Introduction

path(HM:"Endothelial dysfunction") positiveCorrelation a(CHEBI:"iron trichloride") View Subject | View Object

In contrast, selectively removing RBCs prevented endothelial denudation and collagen exposure, resulting in a relatively mild perturbation of endothelial function similar to that observed with FeCl3 alone (data not shown). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Blood
Text Location
Introduction

path(HM:"Endothelial dysfunction") positiveCorrelation complex(a(CHEBI:"iron trichloride"), a(CHEBI:methemoglobin)) View Subject | View Object

Topical treatment with 6% FeCl3 with hemin (1mM) perfusions caused no greater endothelial injury than FeCl3 or hemin (1 mM) alone (data not shown), whereas FeCl3 in the presence of low concentrations of metHb (0.38 mg/ml) induced extensive vascular injury similar to that observed with FeCl3 in the presence of whole blood (Figs. 4 and 1D, respectively). PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

path(HM:"Endothelial dysfunction") positiveCorrelation complex(a(CHEBI:"iron trichloride"), a(CHEBI:methemoglobin)) View Subject | View Object

Third, reintroduction of washed RBCs or purified metHb in the presence of FeCl3 led to a similar level of vascular injury as observed with whole blood, whereas isolated RBC membranes and heme, even in the presence of FeCl3, produced relatively mild injury. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Discussion

path(HM:"Endothelial dysfunction") positiveCorrelation a(HM:"Atheroma lipid") View Subject | View Object

As shown in Fig 3B, lipids from atherosclerotic lesions were cytotoxic to endothelium, an effect strikingly enhanced when lipids were pre-oxidized by exposure to heme. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

path(HM:"Endothelial dysfunction") positiveCorrelation path(MESH:Thrombosis) View Subject | View Object

The triad consists of hypercoagulability, blood stasis and endothelial injury/dysfunction, which are useful concepts for understanding thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Text Location
Review

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.