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a(HM:"Atheroma lipid")

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Entity

Name
Atheroma lipid
Namespace
HM
Namespace Version
None
Pattern
.*

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 11

a(CHEBI:"monounsaturated fatty acid") positiveCorrelation a(HM:"Atheroma lipid") View Subject | View Object

Moreover, lipids extracted from atheromatous lesions contained 1.9 times more monounsaturated fatty acids than control extracts. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(CHEBI:"phosphatidyl-L-serine") negativeCorrelation a(HM:"Atheroma lipid") View Subject | View Object

Elevated cholesterol, oxy-cholesterol, lyso-phospholipid and decreased phosphatidylserine were found in atheromatous lipids compared to controls (supplemental Table II). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(CHEBI:cholesterol) positiveCorrelation a(HM:"Atheroma lipid") View Subject | View Object

Elevated cholesterol, oxy-cholesterol, lyso-phospholipid and decreased phosphatidylserine were found in atheromatous lipids compared to controls (supplemental Table II). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(MESH:"5,6-epoxycholesterol") positiveCorrelation a(HM:"Atheroma lipid") View Subject | View Object

Elevated cholesterol, oxy-cholesterol, lyso-phospholipid and decreased phosphatidylserine were found in atheromatous lipids compared to controls (supplemental Table II). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

complex(a(CHEBI:heme), a(HM:"Atheroma lipid")) hasComponent a(HM:"Atheroma lipid") View Subject | View Object

Appears in Networks:

complex(a(HM:"Atheroma lipid"), p(HGNC:HBB)) hasComponent a(HM:"Atheroma lipid") View Subject | View Object

Appears in Networks:

path(HM:"Endothelial dysfunction") positiveCorrelation a(HM:"Atheroma lipid") View Subject | View Object

As shown in Fig 3B, lipids from atherosclerotic lesions were cytotoxic to endothelium, an effect strikingly enhanced when lipids were pre-oxidized by exposure to heme. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

rxn(reactants(a(CHEBI:heme), a(HM:"Atheroma lipid")), products(a(CHEBI:"lipid hydroperoxide"))) hasReactant a(HM:"Atheroma lipid") View Subject | View Object

Appears in Networks:

rxn(reactants(a(CHEBI:heme), a(HM:"Atheroma lipid")), products(a(MESH:"Thiobarbituric Acid Reactive Substances"))) hasReactant a(HM:"Atheroma lipid") View Subject | View Object

Appears in Networks:

rxn(reactants(a(HM:"Atheroma lipid"), a(HM:ferrihemoglobin)), products(a(CHEBI:"lipid hydroperoxide"))) hasReactant a(HM:"Atheroma lipid") View Subject | View Object

Appears in Networks:

rxn(reactants(a(HM:"Atheroma lipid"), a(HM:ferrihemoglobin)), products(a(MESH:"Thiobarbituric Acid Reactive Substances"))) hasReactant a(HM:"Atheroma lipid") View Subject | View Object

Appears in Networks:

Out-Edges 10

a(HM:"Atheroma lipid") increases a(HM:"Erythrocytes, lysed") View Subject | View Object

Lipids of atheromatous (Fig 1A, 1b and 2b panels) and ruptured complicated lesions (Fig 1A, 1c and 2c panels) as well as oxidized LDL caused significant lysis of red cells within 24 hours (Fig 1B, black bars). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(HM:"Atheroma lipid") increases p(HGNC:HBB, pmod(Ox)) View Subject | View Object

Indeed, lipids derived from atheromatous lesions promoted the oxidation of ferrohemoglobin to ferrihemoglobin (Fig 2C). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(HM:"Atheroma lipid") positiveCorrelation path(HM:"Endothelial dysfunction") View Subject | View Object

As shown in Fig 3B, lipids from atherosclerotic lesions were cytotoxic to endothelium, an effect strikingly enhanced when lipids were pre-oxidized by exposure to heme. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(HM:"Atheroma lipid") increases p(HGNC:HMOX1) View Subject | View Object

At sublethal doses, atheroma lipid - whether pre-treated with heme or not - induced the expression of the stress-responsive gene HO-1, at both mRNA (Fig 3C) and protein levels (Fig 3D). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(HM:"Atheroma lipid") increases r(HGNC:HMOX1) View Subject | View Object

At sublethal doses, atheroma lipid - whether pre-treated with heme or not - induced the expression of the stress-responsive gene HO-1, at both mRNA (Fig 3C) and protein levels (Fig 3D). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(HM:"Atheroma lipid") positiveCorrelation a(CHEBI:cholesterol) View Subject | View Object

Elevated cholesterol, oxy-cholesterol, lyso-phospholipid and decreased phosphatidylserine were found in atheromatous lipids compared to controls (supplemental Table II). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(HM:"Atheroma lipid") positiveCorrelation a(MESH:"5,6-epoxycholesterol") View Subject | View Object

Elevated cholesterol, oxy-cholesterol, lyso-phospholipid and decreased phosphatidylserine were found in atheromatous lipids compared to controls (supplemental Table II). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(HM:"Atheroma lipid") negativeCorrelation a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

Elevated cholesterol, oxy-cholesterol, lyso-phospholipid and decreased phosphatidylserine were found in atheromatous lipids compared to controls (supplemental Table II). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(HM:"Atheroma lipid") positiveCorrelation a(CHEBI:"monounsaturated fatty acid") View Subject | View Object

Moreover, lipids extracted from atheromatous lesions contained 1.9 times more monounsaturated fatty acids than control extracts. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(HM:"Atheroma lipid") increases bp(MESH:"Cytotoxicity, Immunologic") View Subject | View Object

We have found that atheroma lipids when oxidized by heme are highly cytotoxic to human endothelial cells, and hemopexin reduced this cytotoxicity. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.