1. Catalog
  2. Nodes
  3. p(HGNC:HBB, pmod(Ox))

p(HGNC:HBB, pmod(Ox))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
HBB
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 6

a(CHEBI:"lipid hydroperoxide") increases p(HGNC:HBB, pmod(Ox)) View Subject | View Object

Hematomas occur in atheromatous lesions and plaque material contains lipid oxidation products including lipid hydroperoxide22 which can mediate not only the oxidation of hemoglobin but might also lyse intact red cells.23 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(HM:"Atheroma lipid") increases p(HGNC:HBB, pmod(Ox)) View Subject | View Object

Indeed, lipids derived from atheromatous lesions promoted the oxidation of ferrohemoglobin to ferrihemoglobin (Fig 2C). PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

a(MESH:"Glutathione Peroxidase") decreases p(HGNC:HBB, pmod(Ox)) View Subject | View Object

Preincubation of lipid extract derived from atheroma, complicated lesion or oxidized LDL with glutathione/glutathione peroxidase (which specifically reduced lipid hydroperoxide to alcohol by 35%, 38% and 90%, respectively) significantly lowered the lytic effect (Fig 1B, empty bars).Oxidation of liberated hemoglobin was also reduced (Fig 1C, empty bars) PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

p(HGNC:HBB) hasVariant p(HGNC:HBB, pmod(Ox)) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:"oxidised LDL"), a(MESH:"Glutathione Peroxidase")) decreases p(HGNC:HBB, pmod(Ox)) View Subject | View Object

Treatment of oxidized LDL (Fig 2B), or atheroma lipids (Fig 2D) with glutathione/glutathione peroxidase lowered the lipid hydroperoxide content as well as the oxidation of hemoglobin. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plaque, Atherosclerotic
Text Location
Results

path(MESH:"Plaque, Atherosclerotic") positiveCorrelation p(HGNC:HBB, pmod(Ox)) View Subject | View Object

Thus, it appears that these extracts oxidize ferrohemoglobin to ferrihemoglobin, thereby leading to heme instability and heme-mediated initiation of lipid peroxidation. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis
Text Location
Discussion

Out-Edges 1

p(HGNC:HBB, pmod(Ox)) positiveCorrelation path(MESH:"Plaque, Atherosclerotic") View Subject | View Object

Thus, it appears that these extracts oxidize ferrohemoglobin to ferrihemoglobin, thereby leading to heme instability and heme-mediated initiation of lipid peroxidation. PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.