a(CHEBI:"lipid hydroperoxide")
Hematomas occur in atheromatous lesions and plaque material contains lipid oxidation products including lipid hydroperoxide22 which can mediate not only the oxidation of hemoglobin but might also lyse intact red cells.23 PubMed:20378845
Concentrations of iron, conjugated dienes and lipid hydroperoxides were elevated by about 2- fold in ruptured complicated lesions, as compared to atheromatous lesions (0.433 ± 0.075 vs. 0.185 ± 0.096 nmol Fe/mg tissue; 0.047 ± 0.019 vs. 0.021 ± 0.003 A234 conjugated dienes/mg tissue and 0.465 ± 0.110 vs. 0.248 ± 0.106 nmol LOOH/mg tissue, respectively) and complicated lesions contained 5.6 times more TBARs than atheromatous lesions (0.028 ± 0.012 vs. 0.005 ± 0.001 nmol/mg tissue). PubMed:20378845
Preincubation of lipid extract derived from atheroma, complicated lesion or oxidized LDL with glutathione/glutathione peroxidase (which specifically reduced lipid hydroperoxide to alcohol by 35%, 38% and 90%, respectively) significantly lowered the lytic effect (Fig 1B, empty bars).Oxidation of liberated hemoglobin was also reduced (Fig 1C, empty bars) PubMed:20378845
Pre-treatment of heme-oxidized lipids with glutathione/glutathione peroxidase reduced the lipid hydroperoxide content (113±30 vs. 74±22 nmol LOOH/mg extract, p<0.01) and inhibited the endothelial cell cytotoxicity by 25% (p<0.05). PubMed:20378845
Levels of conjugated dienes, lipid hydroperoxides and TBARs were significantly higher in atheromatous lesions compared to controls (supplemental Table I). PubMed:20378845
Treatment of oxidized LDL (Fig 2B), or atheroma lipids (Fig 2D) with glutathione/glutathione peroxidase lowered the lipid hydroperoxide content as well as the oxidation of hemoglobin. PubMed:20378845
As is true of intact hemoglobin, lipid extracts from atheromatous lesions exposed to heme also underwent lipid peroxidation as reflected by the accumulation of thiobarbituric acid-reactive substances (TBARs) and lipid hydroperoxides (supplemental Fig I). PubMed:20378845
GPx removes both H2O2 and organic hydroperoxides [8,31] whereas PRDX2 removes H2O2 [2], organic hydroperoxides, lipid hydroperoxides, [32,33] peroxynitrite [34] and protein hydroperoxides [35]. PubMed:23215741
Hematomas occur in atheromatous lesions and plaque material contains lipid oxidation products including lipid hydroperoxide22 which can mediate not only the oxidation of hemoglobin but might also lyse intact red cells.23 PubMed:20378845
Hematomas occur in atheromatous lesions and plaque material contains lipid oxidation products including lipid hydroperoxide22 which can mediate not only the oxidation of hemoglobin but might also lyse intact red cells.23 PubMed:20378845
Levels of conjugated dienes, lipid hydroperoxides and TBARs were significantly higher in atheromatous lesions compared to controls (supplemental Table I). PubMed:20378845
Concentrations of iron, conjugated dienes and lipid hydroperoxides were elevated by about 2- fold in ruptured complicated lesions, as compared to atheromatous lesions (0.433 ± 0.075 vs. 0.185 ± 0.096 nmol Fe/mg tissue; 0.047 ± 0.019 vs. 0.021 ± 0.003 A234 conjugated dienes/mg tissue and 0.465 ± 0.110 vs. 0.248 ± 0.106 nmol LOOH/mg tissue, respectively) and complicated lesions contained 5.6 times more TBARs than atheromatous lesions (0.028 ± 0.012 vs. 0.005 ± 0.001 nmol/mg tissue). PubMed:20378845
GPx removes both H2O2 and organic hydroperoxides [8,31] whereas PRDX2 removes H2O2 [2], organic hydroperoxides, lipid hydroperoxides, [32,33] peroxynitrite [34] and protein hydroperoxides [35]. PubMed:23215741
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.