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Entity

Name
phosphatase-activating domain
Namespace
HBP
Namespace Version
20181128
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/7e4be528f12abd28be768b62402fba6e083eaf9e/export/hbp-names.belns

Appears in Networks 1

In-Edges 31

a(HBP:"Corticobasal Degeneration") association a(HBP:"phosphatase-activating domain") View Subject | View Object

In CBD, the characteristic astrocytic pathology (e.g. astrocytic plaques) showed extensive co-localization between TNT1, TOC1 and R1 in the frontal cortex (Fig. 5I–L). PubMed:27574109

a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

In contrast, AD soluble tau displayed the highest level of TNT1 followed by CBD, with PiD having the lowest levels (Fig. 6C; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 24.87, p = 0.0002). PubMed:27574109

a(HBP:"Tau isoform B (381 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

a(HBP:"Tau isoform C (410 aa)") association a(HBP:"phosphatase-activating domain") View Subject | View Object

Comparisons between isoform monomers showed that hT39 monomer signal was significantly higher than hT24 and hT23 monomers (Kruskal-Wallis ANOVA with Dunn’s post-hoc, H = 18.4, p = 0.0025) PubMed:27574109

a(HBP:"Tau isoform C (410 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

a(HBP:"Tau isoform D (383 aa)") association a(HBP:"phosphatase-activating domain") View Subject | View Object

Comparisons between isoform monomers showed that hT39 monomer signal was significantly higher than hT24 and hT23 monomers (Kruskal-Wallis ANOVA with Dunn’s post-hoc, H = 18.4, p = 0.0025) PubMed:27574109

a(HBP:"Tau isoform D (383 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

a(HBP:"Tau isoform E (412 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

a(HBP:"Tau isoform F (441 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

a(HBP:"Tau isoform Fetal-tau (352 aa)") association a(HBP:"phosphatase-activating domain") View Subject | View Object

Comparisons between isoform monomers showed that hT39 monomer signal was significantly higher than hT24 and hT23 monomers (Kruskal-Wallis ANOVA with Dunn’s post-hoc, H = 18.4, p = 0.0025) PubMed:27574109

a(HBP:"Tau isoform Fetal-tau (352 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

a(MESH:"Neurofibrillary Tangles") association a(HBP:"phosphatase-activating domain") View Subject | View Object

In severe AD cases (i.e. Braak stage V-VI), all markers continue to colocalize in classic NFTs within the hippocampus that characterize AD tau pathology (Fig. 5E–H) PubMed:27574109

p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

The hT24 aggregates showed the highest TNT1 signal, which reached significance compared to hT40, hT39, hT37 and hT23 aggregates (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.11, p < 0.0001) PubMed:27574109

p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

The hT24 aggregates showed the highest TNT1 signal, which reached significance compared to hT40, hT39, hT37 and hT23 aggregates (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.11, p < 0.0001) PubMed:27574109

p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

The hT24 aggregates showed the highest TNT1 signal, which reached significance compared to hT40, hT39, hT37 and hT23 aggregates (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.11, p < 0.0001) PubMed:27574109

p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

The hT24 aggregates showed the highest TNT1 signal, which reached significance compared to hT40, hT39, hT37 and hT23 aggregates (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.11, p < 0.0001) PubMed:27574109

p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

The hT24 aggregates showed the highest TNT1 signal, which reached significance compared to hT40, hT39, hT37 and hT23 aggregates (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.11, p < 0.0001) PubMed:27574109

p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

In contrast, AD soluble tau displayed the highest level of TNT1 followed by CBD, with PiD having the lowest levels (Fig. 6C; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 24.87, p = 0.0002). PubMed:27574109

path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

In contrast, AD soluble tau displayed the highest level of TNT1 followed by CBD, with PiD having the lowest levels (Fig. 6C; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 24.87, p = 0.0002). PubMed:27574109

path(MESH:Tauopathies) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

In general, the remarkable co-localization between TNT1, TOC1 and R1 in all tauopathies confirms that PAD exposure and tau oligomerization occur simultaneously in cells displaying tau pathology, irrespective of isoform composition PubMed:27574109

Out-Edges 30

a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform Fetal-tau (352 aa)") View Subject | View Object

Comparisons between isoform monomers showed that hT39 monomer signal was significantly higher than hT24 and hT23 monomers (Kruskal-Wallis ANOVA with Dunn’s post-hoc, H = 18.4, p = 0.0025) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform Fetal-tau (352 aa)") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform D (383 aa)") View Subject | View Object

Comparisons between isoform monomers showed that hT39 monomer signal was significantly higher than hT24 and hT23 monomers (Kruskal-Wallis ANOVA with Dunn’s post-hoc, H = 18.4, p = 0.0025) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform D (383 aa)") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform C (410 aa)") View Subject | View Object

Comparisons between isoform monomers showed that hT39 monomer signal was significantly higher than hT24 and hT23 monomers (Kruskal-Wallis ANOVA with Dunn’s post-hoc, H = 18.4, p = 0.0025) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform C (410 aa)") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

The hT24 aggregates showed the highest TNT1 signal, which reached significance compared to hT40, hT39, hT37 and hT23 aggregates (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.11, p < 0.0001) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

The hT24 aggregates showed the highest TNT1 signal, which reached significance compared to hT40, hT39, hT37 and hT23 aggregates (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.11, p < 0.0001) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

The hT24 aggregates showed the highest TNT1 signal, which reached significance compared to hT40, hT39, hT37 and hT23 aggregates (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.11, p < 0.0001) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

The hT24 aggregates showed the highest TNT1 signal, which reached significance compared to hT40, hT39, hT37 and hT23 aggregates (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.11, p < 0.0001) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

The hT24 aggregates showed the highest TNT1 signal, which reached significance compared to hT40, hT39, hT37 and hT23 aggregates (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.11, p < 0.0001) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform B (381 aa)") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform F (441 aa)") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform E (412 aa)") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

a(HBP:"phosphatase-activating domain") association a(MESH:"Neurofibrillary Tangles") View Subject | View Object

In severe AD cases (i.e. Braak stage V-VI), all markers continue to colocalize in classic NFTs within the hippocampus that characterize AD tau pathology (Fig. 5E–H) PubMed:27574109

a(HBP:"phosphatase-activating domain") association a(HBP:"Corticobasal Degeneration") View Subject | View Object

In CBD, the characteristic astrocytic pathology (e.g. astrocytic plaques) showed extensive co-localization between TNT1, TOC1 and R1 in the frontal cortex (Fig. 5I–L). PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Corticobasal Degeneration") View Subject | View Object

In contrast, AD soluble tau displayed the highest level of TNT1 followed by CBD, with PiD having the lowest levels (Fig. 6C; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 24.87, p = 0.0002). PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:Tauopathies) View Subject | View Object

In general, the remarkable co-localization between TNT1, TOC1 and R1 in all tauopathies confirms that PAD exposure and tau oligomerization occur simultaneously in cells displaying tau pathology, irrespective of isoform composition PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

In contrast, AD soluble tau displayed the highest level of TNT1 followed by CBD, with PiD having the lowest levels (Fig. 6C; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 24.87, p = 0.0002). PubMed:27574109

a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Pick Disease of the Brain") View Subject | View Object

In contrast, AD soluble tau displayed the highest level of TNT1 followed by CBD, with PiD having the lowest levels (Fig. 6C; one-way ANOVA with Holm-Sidak post-hoc, F(2,9) = 24.87, p = 0.0002). PubMed:27574109

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.