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p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation"))

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Entity

Name
Tau isoform F (441 aa)
Namespace
HBP
Namespace Version
20181128
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/7e4be528f12abd28be768b62402fba6e083eaf9e/export/hbp-names.belns

Appears in Networks 1

Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition v1.0.1

In-Edges 3

a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

The hT24 aggregates showed the highest TNT1 signal, which reached significance compared to hT40, hT39, hT37 and hT23 aggregates (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.11, p < 0.0001) PubMed:27574109

Appears in Networks:

a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)") hasVariant p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) View Subject | View Object

Appears in Networks:

Out-Edges 7

p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

The hT24 aggregates showed the highest TNT1 signal, which reached significance compared to hT40, hT39, hT37 and hT23 aggregates (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.11, p < 0.0001) PubMed:27574109

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

Aggregates of all six tau isoforms showed significant increases in TNT1 reactivity when compared to their respective monomer samples (Fig. 3A; Mann-Whitney test, for all comparisons p = 0.029) PubMed:27574109

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") View Subject | View Object

The hT24 aggregates showed the highest TOC1 signal, which reached significance compared to hT40, hT39, hT37 and hT23 aggregates, while hT34 aggregates were significantly different from hT39, hT37 and hT23 aggregates, and both hT40 and hT39 aggregates are significantly higher than hT37 and hT23 (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 50.77, p < 0.0001) PubMed:27574109

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") View Subject | View Object

Aggregated samples for all six isoforms showed significant increases in TOC1 reactivity when compared to their respective monomer samples (Fig. 3B; Mann-Whitney tests, for all comparisons p = 0.029) PubMed:27574109

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") View Subject | View Object

Perfusion of hT40, hT34 and hT24 aggregates into squid axoplasms significantly impaired anterograde transport (Fig. 4A) when compared to the respective monomers (all at 2 μM). PubMed:27574109

Appears in Networks:
Annotations
MeSH
Axons
MeSH
Cytoplasm

p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") View Subject | View Object

hT40, hT34, hT24, hT37 and hT23 aggregates did not significantly impair retrograde FAT when compared to the respective monomers, but hT39 aggregates elicited a mild inhibitory effect on retrograde FAT (Fig. 4B) PubMed:27574109

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.