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a(HBP:"Braak_Stage II")

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Entity

Name
Braak_Stage II
Namespace
HBP
Namespace Version
20181128
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/7e4be528f12abd28be768b62402fba6e083eaf9e/export/hbp-names.belns

Appears in Networks 3

Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition v1.0.1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

In-Edges 5

a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage II") View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage II") View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

p(HGNC:MAPT) association a(HBP:"Braak_Stage II") View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage II") View Subject | View Object

We found that GSK3β mRNA was overexpressed only in patients with initial AD, with no effect on the levels of the protein. On the other hand, we unexpectedly observed the decrease of the inactive GSK3β in cortex from AD patients at Braak stages I-II, whereas considerable increase was observed in AD patients at stages V-VI compared to the control subjects. PubMed:28176663

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(GO:"regulation of endosome size") association a(HBP:"Braak_Stage II") View Subject | View Object

Neuronal endosome enlargement, which is not characteristically observed in other major neurodegenerative diseases, develops in pyramidal neurons of the neocortex at a stage when plaques and tangles are restricted only to the hippocampus (Braak stage 2) and not in brains of similarly aged individuals free of AD-like hippocampal pathology (Cataldo et al. 1997, 2000). PubMed:22908190

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Neurons
MeSH
Pyramidal Cells

Out-Edges 5

a(HBP:"Braak_Stage II") association a(HBP:"Tau oligomers") View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

a(HBP:"Braak_Stage II") association a(HBP:"phosphatase-activating domain") View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

a(HBP:"Braak_Stage II") association p(HGNC:MAPT) View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

a(HBP:"Braak_Stage II") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) View Subject | View Object

We found that GSK3β mRNA was overexpressed only in patients with initial AD, with no effect on the levels of the protein. On the other hand, we unexpectedly observed the decrease of the inactive GSK3β in cortex from AD patients at Braak stages I-II, whereas considerable increase was observed in AD patients at stages V-VI compared to the control subjects. PubMed:28176663

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(HBP:"Braak_Stage II") association bp(GO:"regulation of endosome size") View Subject | View Object

Neuronal endosome enlargement, which is not characteristically observed in other major neurodegenerative diseases, develops in pyramidal neurons of the neocortex at a stage when plaques and tangles are restricted only to the hippocampus (Braak stage 2) and not in brains of similarly aged individuals free of AD-like hippocampal pathology (Cataldo et al. 1997, 2000). PubMed:22908190

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Neurons
MeSH
Pyramidal Cells

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.