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a(HBP:"Tau isoform Fetal-tau (352 aa)")

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Entity

Name
Tau isoform Fetal-tau (352 aa)
Namespace
HBP
Namespace Version
20181128
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/7e4be528f12abd28be768b62402fba6e083eaf9e/export/hbp-names.belns

Appears in Networks 1

Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition v1.0.1

In-Edges 2

a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform Fetal-tau (352 aa)") View Subject | View Object

Comparisons between isoform monomers showed that hT39 monomer signal was significantly higher than hT24 and hT23 monomers (Kruskal-Wallis ANOVA with Dunn’s post-hoc, H = 18.4, p = 0.0025) PubMed:27574109

Appears in Networks:

a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform Fetal-tau (352 aa)") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

Appears in Networks:

Out-Edges 4

a(HBP:"Tau isoform Fetal-tau (352 aa)") association a(HBP:"phosphatase-activating domain") View Subject | View Object

Comparisons between isoform monomers showed that hT39 monomer signal was significantly higher than hT24 and hT23 monomers (Kruskal-Wallis ANOVA with Dunn’s post-hoc, H = 18.4, p = 0.0025) PubMed:27574109

Appears in Networks:

a(HBP:"Tau isoform Fetal-tau (352 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

Appears in Networks:

a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers") View Subject | View Object

Comparisons between isoform monomers showed that hT39 monomer signal was significantly higher than hT24 and hT23 monomers (Kruskal-Wallis ANOVA with Dunn’s post-hoc, H = 18.6, p = 0.0023) PubMed:27574109

Appears in Networks:

a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers") View Subject | View Object

As expected, monomer and aggregated samples of all six tau isoforms showed equal reactivity for TNT1 and TOC1 when the samples were denatured because this exposes the epitopes making them equally accessible (Student’s t-tests, for all comparisons p > 0.05; Fig. 3C–H) PubMed:27574109

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.