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a(HBP:"Braak_Stage I")

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Entity

Name
Braak_Stage I
Namespace
HBP
Namespace Version
20181128
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/7e4be528f12abd28be768b62402fba6e083eaf9e/export/hbp-names.belns

Appears in Networks 2

Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition v1.0.1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 4

a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage I") View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage I") View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

p(HGNC:MAPT) association a(HBP:"Braak_Stage I") View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage I") View Subject | View Object

We found that GSK3β mRNA was overexpressed only in patients with initial AD, with no effect on the levels of the protein. On the other hand, we unexpectedly observed the decrease of the inactive GSK3β in cortex from AD patients at Braak stages I-II, whereas considerable increase was observed in AD patients at stages V-VI compared to the control subjects. PubMed:28176663

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Out-Edges 4

a(HBP:"Braak_Stage I") association a(HBP:"Tau oligomers") View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

a(HBP:"Braak_Stage I") association a(HBP:"phosphatase-activating domain") View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

a(HBP:"Braak_Stage I") association p(HGNC:MAPT) View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

a(HBP:"Braak_Stage I") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) View Subject | View Object

We found that GSK3β mRNA was overexpressed only in patients with initial AD, with no effect on the levels of the protein. On the other hand, we unexpectedly observed the decrease of the inactive GSK3β in cortex from AD patients at Braak stages I-II, whereas considerable increase was observed in AD patients at stages V-VI compared to the control subjects. PubMed:28176663

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.