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a(HBP:pretangles)

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Entity

Name
pretangles
Namespace
HBP
Namespace Version
20181128
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/7e4be528f12abd28be768b62402fba6e083eaf9e/export/hbp-names.belns

Appears in Networks 3

Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition v1.0.1

Tau Biochemistry v1.2.5

Tau Biochemistry Section of NESTOR

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 9

a(HBP:"Tau oligomers") association a(HBP:pretangles) View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

p(HGNC:MAPT) association a(HBP:pretangles) View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

a(HBP:"phosphatase-activating domain") association a(HBP:pretangles) View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

p(HBP:"4R tau") partOf a(HBP:pretangles) View Subject | View Object

Appears in Networks:

a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(HBP:pretangles) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:pretangles) View Subject | View Object

These data suggest a role for TTBK1 in pre-tangle formation prior to the formation of fibrillar tau and strengthen the idea that tau is phosphorylated at Ser422 at an early intermediate stage in NFT formation. PubMed:18239272

Appears in Networks:

p(HGNC:SYK) partOf a(HBP:pretangles) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK1) association a(HBP:pretangles) View Subject | View Object

These data suggest a role for TTBK1 in pre-tangle formation prior to the formation of fibrillar tau and strengthen the idea that tau is phosphorylated at Ser422 at an early intermediate stage in NFT formation. PubMed:18239272

Appears in Networks:

p(MGI:Ttbk1) increases a(HBP:pretangles) View Subject | View Object

Overexpression of TTBK1 was sufficient in inducing spatial learning impairment in mice, which is associated with enhanced Cdk5 activity and reduction in cell surface level of NR2B. Over-expressionof TTBK1 transgene in JNPL3 mice resulted in accumulation of pre-tangle forms of tau. Inaddition, TTBK1 expression plays a unique role in accelerating motor neuron degeneration and neuroinflammation in JNPL3mice. PubMed:24808823

Appears in Networks:

Out-Edges 7

a(HBP:pretangles) association a(HBP:"Tau oligomers") View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

a(HBP:pretangles) association a(HBP:"phosphatase-activating domain") View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

a(HBP:pretangles) association p(HGNC:MAPT) View Subject | View Object

Indeed, early pre-tangle neurons within the hippocampus were labeled with all antibodies in Braak I-II cases (Fig. 5A–D) PubMed:27574109

Appears in Networks:
Annotations
MeSH
Hippocampus

a(HBP:pretangles) increases complex(GO:"dendritic tree") View Subject | View Object

Dendritic arborization was abundant in RD3-/4+ pretangles, attenuated in RD3+/4+ neurons, and further attenuated in RD3+/4- ghost tangles. PubMed:23407988

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

a(HBP:pretangles) association p(HGNC:TTBK1) View Subject | View Object

These data suggest a role for TTBK1 in pre-tangle formation prior to the formation of fibrillar tau and strengthen the idea that tau is phosphorylated at Ser422 at an early intermediate stage in NFT formation. PubMed:18239272

Appears in Networks:

a(HBP:pretangles) association p(HGNC:MAPT, pmod(Ph, Ser, 422)) View Subject | View Object

These data suggest a role for TTBK1 in pre-tangle formation prior to the formation of fibrillar tau and strengthen the idea that tau is phosphorylated at Ser422 at an early intermediate stage in NFT formation. PubMed:18239272

Appears in Networks:

a(HBP:pretangles) isA a(GO:"neurofibrillary tangle") View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.