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p(MGI:Tnf)

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Entity

Name
Tnf
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 4

Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation v1.0.0

Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine v1.0.0

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 16

a(CHEBI:Anatabine) decreases p(MGI:Tnf) View Subject | View Object

Following 90 days of treatment with anatabine, a significant reduction in brain TNF-a (Mann–Whitney U=6, Z=-2.146, p=0.032) and in IL-6 (Mann–Whitney U=0, Z=-2.887, p=0.004) was observed in Tg APPsw mice compared to Tg APPsw that received regular drinking water (Fig. 9) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) View Subject | View Object

Our results showed that intraperitoneal injection of LPS (1 mg/kg) caused a significant elevation of plasma IL-1b (Mann–Whitney U=3, Z=-2.988, P=0.003), IL-6 (Mann–Whitney U=0, Z=-3.366, P=0.001) and TNFa (Mann– Whitney U=0, Z=-3.508, P<0.001) 4 h after the LPS challenge whereas in mice co-treated with an intraperitoneal injection of anatabine (2 mg/kg) and LPS, a significant reduction in plasma IL-1b (Mann–Whitney U=7, Z=-2.645, P=0.008) and TNFa (Mann–Whitney U=4, Z=-2.941, P=0.003) levels was observed (Fig. 6) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Plasma

a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) View Subject | View Object

An elevation of IL-6 (Mann–Whitney U=0, Z=-3.487, P<0.001), IL1b (Mann– Whitney U=0, Z=-3.24, P=0.001) and TNFa (Mann–Whitney U=0, Z=-3.361, P=0.001) was observed in the spleen of LPS challenged mice (Fig. 7) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Spleen

a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) View Subject | View Object

Similarly, IL-1b (Mann–Whitney U=0, Z=-3.098, P=0.002), IL-6 (Mann–Whitney U=0, Z=-3.363, P<0.001) and TNF-a levels (Mann–Whitney U=0, Z=-3.361, P=0.001) were elevated in the kidney following the LPS challenge (data not shown) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Kidney

composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) View Subject | View Object

Our results showed that intraperitoneal injection of LPS (1 mg/kg) caused a significant elevation of plasma IL-1b (Mann–Whitney U=3, Z=-2.988, P=0.003), IL-6 (Mann–Whitney U=0, Z=-3.366, P=0.001) and TNFa (Mann– Whitney U=0, Z=-3.508, P<0.001) 4 h after the LPS challenge whereas in mice co-treated with an intraperitoneal injection of anatabine (2 mg/kg) and LPS, a significant reduction in plasma IL-1b (Mann–Whitney U=7, Z=-2.645, P=0.008) and TNFa (Mann–Whitney U=4, Z=-2.941, P=0.003) levels was observed (Fig. 6) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Plasma

composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) View Subject | View Object

Anatabine significantly inhibited LPS induced IL-6 (Mann–Whitney U=4, Z=-3.303, P=0.001), TNF-a (Mann–Whitney U=0, Z=-3.361, P=0.001) and IL-1b levels in the spleen (Mann–Whitney U=9, Z=-1.981, P=0.048) (Fig. 7) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Spleen

composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) View Subject | View Object

A significant reduction in TNF-a (Mann–Whitney U=12, Z=-2.309, P=0.021) but no significant reduction in IL-6 levels (Mann–Whitney U=25, Z=-1.223, P=0.221) or IL-1b (Mann–Whitney U=8, Z=-1.857,P=0.063) were observed in the kidney of LPS and anatabine cotreated animals (data not shown) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Kidney

a(CHEBI:Anatabine) decreases p(MGI:Tnf) View Subject | View Object

Anatabine appears to fully suppress IL-1b, INF-gamma and TNF-a elevation in the spleen of EAE mice (Fig. 2C). PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spleen
MeSH
Encephalomyelitis

path(MESH:"Alzheimer Disease") increases p(MGI:Tnf) View Subject | View Object

An elevation of brain IL-6 (Mann–Whitney U=0, Z=-3, p=0.003) and TNF-a (Mann–Whitney U=0, Z=-2.887, p=0.004) was observed in Tg APPsw mice compared to their wild-type littermates (Fig. 9) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

a(CHEBI:Anatabine) causesNoChange p(MGI:Tnf) View Subject | View Object

However, anatabine significantly suppressed the production of IL-1b, IL-6 and IL-17A in the serum of EAE mice (Fig. 2B) but did not significantly impact IFN-gamma and TNF-alpha PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum
MeSH
Encephalomyelitis

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Tnf) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

path(MESH:Encephalomyelitis) increases p(MGI:Tnf) View Subject | View Object

A significant elevation of IL-1b, INF-gamma and TNF-alpha was observed in the spleen of EAE mice compared to control non immunized animals PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spleen

a(GO:"neurofibrillary tangle") increases act(p(MGI:Tnf)) View Subject | View Object

Consistent with NFTs from human AD, mouse NFTs also caused significant activation scores for IFNG, TNF, IL-1B, as well as enrichment in other senescence associated JAK, STAT, CDKN2A and BCL2 predicted upstream regulators (Figure 1c) indicating translational relevance for using tauNFT mice to explore our hypothesis PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tnf) View Subject | View Object

Consistent with the transcriptomic profile in human NFT-bearing neurons and mouse brain tissue (Figure 1a-c), SASP genes were found to be upregulated in tauNFT brains, i.e., Il1b was 4- and 2-fold higher than CTL and tauWT, respectively; and Cxcl1 was 4-fold higher than both control genotypes; Tnfa was 13- and 8-fold higher than CTL and tauWT, respectively; Tlr4 was 3-fold higher than both control genotypes (Figure 2a-d) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

a(CHEBI:heme) positiveCorrelation p(MGI:Tnf) View Subject | View Object

However, a weak TNF-alpha signal appeared in macrophages that were treated with the highest concentration of NaOH-dissolved heme (500 lmolL1). PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Mitochondria
Text Location
Results

p(MGI:Hpx) decreases p(MGI:Tnf) View Subject | View Object

Here we show that Hx treatment decreases expression of the M1 cytokine TNFα, the monocyte chemoattractant protein (MCP)1, and the profibrotic and mitogenic cytokines transforming growth factor (TGF)β and platelet-derived growth factor (PDGF) in the liver of sickle mice. PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

Out-Edges 2

p(MGI:Tnf) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

p(MGI:Tnf) positiveCorrelation a(CHEBI:heme) View Subject | View Object

However, a weak TNF-alpha signal appeared in macrophages that were treated with the highest concentration of NaOH-dissolved heme (500 lmolL1). PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Mitochondria
Text Location
Results

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.