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path(MESH:"Disseminated Intravascular Coagulation")

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Entity

Name
Disseminated Intravascular Coagulation
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 14

a(CHEBI:Thrombin) positiveCorrelation path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

However, 6 years later, Heyes and co-workers demonstrated in an experimental study in rats that infusions of thrombin induce DIC accompanied with hemolysis and schistocytosis [89]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Adenocarcinoma
Text Location
Review

a(CHEBI:argatroban) decreases path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

Recently, using a rat model of lipopolysaccharide (LPS)-induced systemic inflammation, our own collaboration could show that argatroban (a specific direct thrombin inhibitor and consequently an inhibitor of coagulation) abolishes DIC, schistocyte formation, and hemolysis. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

a(CHEBI:eptifibatide) causesNoChange path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

Interestingly, inhibition of coagulation is capable of diminishing DIC and hemolysis but not antiplatelet therapy—treatment with eptifibatide (an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class) failed to reduce LPS-induced DIC, schistocyte formation, and hemolysis. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

a(HM:"ABO-incompatible erythrocytes") positiveCorrelation path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

Surprisingly, 66% (187/282) of ABO incompatible transfusions are asymptomatic; however, 67% (19/282) result in death and 27% (76/282) in major morbidities (Bolton-Maggs et al, 2014), including DIC (Goldfinger, 1977). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Cell Adhesion Molecules") increases path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

Essential for the development of DIC during sepsis is the so-called pro-coagulatory shift of the endothelial cells, caused among others by an increased expression of tissue factor and adhesion molecules especially by damaged endothelial cells [87]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Sepsis
Text Location
Review

p(HGNC:F3) increases path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

Essential for the development of DIC during sepsis is the so-called pro-coagulatory shift of the endothelial cells, caused among others by an increased expression of tissue factor and adhesion molecules especially by damaged endothelial cells [87]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Sepsis
Text Location
Review

path(HM:"endothelial lesions") increases path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

During HUS, endothelial lesions cause a complement dependent activation of immune response and local thrombus formation—attachment of fibrin and platelets to the endothelial lesions and consequently disseminated intravascular coagulation (DIC)—and further mechanical destruction of the red blood cells in the fibrin mesh resulting in hemolysis [82]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Atypical Hemolytic Uremic Syndrome
Text Location
Review

path(HP:"Microangiopathic hemolytic anemia") positiveCorrelation path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

They concluded that intravascular coagulation must be the most likely cause of this microangiopathic hemolytic anemia. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Adenocarcinoma
Text Location
Review

path(MESH:Hemolysis) positiveCorrelation path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

Although haemolysis and thrombosis are hallmarks of the thrombo microangiopathies, such as disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS), it is difficult to isolate the causative role of haemolysis in the pathophysiology of thrombosis in these complex disorders. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

path(MESH:Hemolysis) positiveCorrelation path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

It is crucial, hence, to further investigate the mechanisms of sepsis-induced hemolysis with the aim of deriving possible therapeutic principles. Herein, we collected the most important previously known triggers of hemolysis during sepsis, which are (1) transfusion reactions and complement activation, (2) disseminated intravascular coagulation, (3) capillary stopped-flow, (4) restriction of glucose to red blood cells, (5) changes in red blood cell membrane properties, (6) hemolytic pathogens, and (7) red blood cell apoptosis. PubMed:29956069

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Annotations
Text Location
Review

path(MESH:Inflammation) association path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

Sepsis/systemic inflammation is frequently associated with disseminated intravascular coagulation (DIC) being a predictor of mortality in septic patients [84, 85]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

path(MESH:Thrombocytopenia) positiveCorrelation path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

DIC is characterized by a systemic intravascular coagulation, formation of microvascular thrombi, insufficiently compensated consumption of platelets and coagulation factors, and eventually bleeding tendency [84]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Sepsis
Text Location
Review

path(MESH:Thrombosis) positiveCorrelation path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

Although haemolysis and thrombosis are hallmarks of the thrombo microangiopathies, such as disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS), it is difficult to isolate the causative role of haemolysis in the pathophysiology of thrombosis in these complex disorders. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

path(MESH:Thrombosis) positiveCorrelation path(MESH:"Disseminated Intravascular Coagulation") View Subject | View Object

DIC is characterized by a systemic intravascular coagulation, formation of microvascular thrombi, insufficiently compensated consumption of platelets and coagulation factors, and eventually bleeding tendency [84]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Sepsis
Text Location
Review

Out-Edges 9

path(MESH:"Disseminated Intravascular Coagulation") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Although haemolysis and thrombosis are hallmarks of the thrombo microangiopathies, such as disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS), it is difficult to isolate the causative role of haemolysis in the pathophysiology of thrombosis in these complex disorders. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

path(MESH:"Disseminated Intravascular Coagulation") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

It is crucial, hence, to further investigate the mechanisms of sepsis-induced hemolysis with the aim of deriving possible therapeutic principles. Herein, we collected the most important previously known triggers of hemolysis during sepsis, which are (1) transfusion reactions and complement activation, (2) disseminated intravascular coagulation, (3) capillary stopped-flow, (4) restriction of glucose to red blood cells, (5) changes in red blood cell membrane properties, (6) hemolytic pathogens, and (7) red blood cell apoptosis. PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Disseminated Intravascular Coagulation") positiveCorrelation path(MESH:Thrombosis) View Subject | View Object

Although haemolysis and thrombosis are hallmarks of the thrombo microangiopathies, such as disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS), it is difficult to isolate the causative role of haemolysis in the pathophysiology of thrombosis in these complex disorders. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

path(MESH:"Disseminated Intravascular Coagulation") positiveCorrelation path(MESH:Thrombosis) View Subject | View Object

DIC is characterized by a systemic intravascular coagulation, formation of microvascular thrombi, insufficiently compensated consumption of platelets and coagulation factors, and eventually bleeding tendency [84]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Sepsis
Text Location
Review

path(MESH:"Disseminated Intravascular Coagulation") positiveCorrelation a(HM:"ABO-incompatible erythrocytes") View Subject | View Object

Surprisingly, 66% (187/282) of ABO incompatible transfusions are asymptomatic; however, 67% (19/282) result in death and 27% (76/282) in major morbidities (Bolton-Maggs et al, 2014), including DIC (Goldfinger, 1977). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

path(MESH:"Disseminated Intravascular Coagulation") association path(MESH:Inflammation) View Subject | View Object

Sepsis/systemic inflammation is frequently associated with disseminated intravascular coagulation (DIC) being a predictor of mortality in septic patients [84, 85]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

path(MESH:"Disseminated Intravascular Coagulation") positiveCorrelation path(MESH:Thrombocytopenia) View Subject | View Object

DIC is characterized by a systemic intravascular coagulation, formation of microvascular thrombi, insufficiently compensated consumption of platelets and coagulation factors, and eventually bleeding tendency [84]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Sepsis
Text Location
Review

path(MESH:"Disseminated Intravascular Coagulation") positiveCorrelation path(HP:"Microangiopathic hemolytic anemia") View Subject | View Object

They concluded that intravascular coagulation must be the most likely cause of this microangiopathic hemolytic anemia. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Adenocarcinoma
Text Location
Review

path(MESH:"Disseminated Intravascular Coagulation") positiveCorrelation a(CHEBI:Thrombin) View Subject | View Object

However, 6 years later, Heyes and co-workers demonstrated in an experimental study in rats that infusions of thrombin induce DIC accompanied with hemolysis and schistocytosis [89]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Adenocarcinoma
Text Location
Review

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.