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bp(GO:"complement activation")

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Entity

Name
complement activation
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 8

a(CHEBI:heme) increases bp(GO:"complement activation") View Subject | View Object

Hemolytic diseases are often accompanied by dysregulation and overactivation of the complement system [72–74], which may be induced by free extracellular heme [33,75–77] (Figure 3B). PubMed:26875449

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Review

a(MESH:"Cell-Derived Microparticles") increases bp(GO:"complement activation") View Subject | View Object

The circulating MPs can internalize free heme and transfer it to vascular endothelium, promoting vaso-occlusion, or amplify systemic inflammation via thrombin mediated activation of the complement system [57]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

bp(MESH:"Cell Membrane Permeability") positiveCorrelation bp(GO:"complement activation") View Subject | View Object

Activation of the complement system and the formation of MAC resulted in an increased membrane permeability and erythrocyte lysis. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

path(HP:"Paroxysmal nocturnal hemoglobinuria") increases bp(GO:"complement activation") View Subject | View Object

In PNH, uncontrolled complement activity leads to systemic complications, principally through intravascular haemolysis and platelet activation. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
Text Location
Review

path(MESH:Hemolysis) positiveCorrelation bp(GO:"complement activation") View Subject | View Object

Erythrocyte lysis after ICH can be mediated by the complement activation and formation of the membrane attack complex (MAC), which contains complement C5b, C6, C7, C8 and C9 proteins (C5b– 9). PubMed:27125525

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Hemolysis) positiveCorrelation bp(GO:"complement activation") View Subject | View Object

Activation of the complement system and the formation of MAC resulted in an increased membrane permeability and erythrocyte lysis. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

path(MESH:Hemolysis) positiveCorrelation bp(GO:"complement activation") View Subject | View Object

It is crucial, hence, to further investigate the mechanisms of sepsis-induced hemolysis with the aim of deriving possible therapeutic principles. Herein, we collected the most important previously known triggers of hemolysis during sepsis, which are (1) transfusion reactions and complement activation, (2) disseminated intravascular coagulation, (3) capillary stopped-flow, (4) restriction of glucose to red blood cells, (5) changes in red blood cell membrane properties, (6) hemolytic pathogens, and (7) red blood cell apoptosis. PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Malaria) association bp(GO:"complement activation") View Subject | View Object

Indeed, the severe forms of malaria are associated with activation of the complement system [74]. PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Anemia, Sickle Cell
Text Location
Review

Out-Edges 8

bp(GO:"complement activation") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Activation of the complement system and the formation of MAC resulted in an increased membrane permeability and erythrocyte lysis. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

bp(GO:"complement activation") association path(MESH:Malaria) View Subject | View Object

Indeed, the severe forms of malaria are associated with activation of the complement system [74]. PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Anemia, Sickle Cell
Text Location
Review

bp(GO:"complement activation") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Erythrocyte lysis after ICH can be mediated by the complement activation and formation of the membrane attack complex (MAC), which contains complement C5b, C6, C7, C8 and C9 proteins (C5b– 9). PubMed:27125525

Appears in Networks:
Annotations
Text Location
Introduction

bp(GO:"complement activation") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

It is crucial, hence, to further investigate the mechanisms of sepsis-induced hemolysis with the aim of deriving possible therapeutic principles. Herein, we collected the most important previously known triggers of hemolysis during sepsis, which are (1) transfusion reactions and complement activation, (2) disseminated intravascular coagulation, (3) capillary stopped-flow, (4) restriction of glucose to red blood cells, (5) changes in red blood cell membrane properties, (6) hemolytic pathogens, and (7) red blood cell apoptosis. PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

bp(GO:"complement activation") increases path(MESH:Hemolysis) View Subject | View Object

Thus, the complement system may be causally involved in the onset of hemolysis during sepsis [74] by directly damaging the red blood cells upon activation as a result of detecting pathogen structures [73]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

bp(GO:"complement activation") positiveCorrelation bp(MESH:"Cell Membrane Permeability") View Subject | View Object

Activation of the complement system and the formation of MAC resulted in an increased membrane permeability and erythrocyte lysis. PubMed:27125525

Appears in Networks:
Annotations
MeSH
Cerebral Hemorrhage
Text Location
Results

bp(GO:"complement activation") increases path(MESH:Inflammation) View Subject | View Object

The circulating MPs can internalize free heme and transfer it to vascular endothelium, promoting vaso-occlusion, or amplify systemic inflammation via thrombin mediated activation of the complement system [57]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

bp(GO:"complement activation") increases bp(MESH:Eryptosis) View Subject | View Object

Eryptosis is tightly regulated and triggered by a wide range of (endogenous) mediators and stimuli such as calcium signaling, ceramide formation, complement activation, energy depletion, eicosanoid release, hemolysin, and heme [140–142]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.