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complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1))

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Components

Appears in Networks 1

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways v1.0.0

In-Edges 2

a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) View Subject | View Object

Ganetespib treatment had a strong effect on most Hsp90- client interactions. Of the 630 unique proteins that we detected by LUMIER assay, 46% significantly decreased their interaction with Hsp90beta (change in LUMIER score > 1.5, adjusted p value <0.05; Figure 4A) PubMed:25036637

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a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) View Subject | View Object

A few, mostly cochaperones, decreased their interaction with both Hsp90b and Hsc70 (blue circles, Figure 4C). PubMed:25036637

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Out-Edges 2

complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) hasComponent p(HGNC:HSP90AB1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) hasComponent p(HGNC:SUGT1) View Subject | View Object

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.