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path(MESH:Attention)

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Entity

Name
Attention
Namespace
mesh
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/mesh-names.belns

Appears in Networks 9

Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia. v1.0.0

This file encodes the article Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer’s disease and schizophrenia by Choi et al, 2014

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System v1.0.0

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

Nicotinic Receptor Abnormalities of Alzheimer’s Disease: Therapeutic Implications v1.0.0

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0

This document contains the curation of the review article Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system by Taly et al. 2009

Discriminative Stimulus Properties of S(−)-Nicotine: “A Drug for All Seasons v1.0.0

In-Edges 18

a(CHEBI:Mecamylamine) decreases path(MESH:Attention) View Subject | View Object

During attention tasks, the nicotinic antagonist, mecamylamine, impaired accuracy or reaction time (151, 152) and nicotinic agonists improved accuracy (153). PubMed:17009926

Appears in Networks:

path(MESH:Schizophrenia) association path(MESH:Attention) View Subject | View Object

The hallmark psychotic symptoms of SZ are the positive cluster and include auditory hallucinations, delusional beliefs, and disorganized thoughts and speech. SZ patients also exhibit negative symptoms, including anhedonia, dysfunctional social interactions, and poverty of thoughts and speech, as well as cognitive disturbances affecting several behavioral domains, including working memory, attention, and executive function PubMed:24511233

Appears in Networks:

a(CHEBI:"nicotinic acetylcholine receptor agonist") increases path(MESH:Attention) View Subject | View Object

During attention tasks, the nicotinic antagonist, mecamylamine, impaired accuracy or reaction time (151, 152) and nicotinic agonists improved accuracy (153). PubMed:17009926

Appears in Networks:

p(FPLX:CHRN) association path(MESH:Attention) View Subject | View Object

By modulating activity-dependent events, nAChRs participate in fundamental aspects of synaptic plasticity that are involved in attention, learning, memory, and development (3, 12–16). PubMed:17009926

Appears in Networks:

act(a(MESH:"Cholinergic Neurons")) increases path(MESH:Attention) View Subject | View Object

Experimental data using non-human primates and rodents have demonstrated that injuries introduced to basal forebrain cholinergic neurons that innervate the cortex lead to attention deficit PubMed:26813123

Appears in Networks:
Annotations
MeSH
Basal Forebrain

a(MESH:"Cholinergic Neurons") increases path(MESH:Attention) View Subject | View Object

All these cholinergic alterations that take place in AD closely correlates with impaired attention and memory observed in patients PubMed:26813123

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(GO:"synaptic transmission, cholinergic") association path(MESH:Attention) View Subject | View Object

The cholinergic system is involved in critical physiological processes, such as attention, learning, memory, stress response, wakefulness and sleep, and sensory information PubMed:26813123

Appears in Networks:

bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) View Subject | View Object

On the other hand, the facilitation of the cholinergic transmission by using the cholinesterase inhibitors can improve attention in humans PubMed:26813123

Appears in Networks:

bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) View Subject | View Object

Disruption of cholinergic inputs to the cortex can impair attention and the use of instructive cues needed for decision-making related to ongoing behavior PubMed:26813123

Appears in Networks:

p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Attention) View Subject | View Object

Members of the mAChR family are widely expressed in various regions in the central nervous system (CNS) and in the peripheral system. They play crucial roles in diverse physiological processes such as memory, attention, nociception, motor control, sleep-wake cycles, and cardiovascular, renal, and gastrointestinal functions PubMed:24590577

Appears in Networks:

a(CHEBI:"(-)-cotinine") increases path(MESH:Attention) View Subject | View Object

Cotinine is a nicotine metabolite known for its positive effects on memory and attention and lower toxicity compared to nicotine (Hatsukami et al., 1997) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(HP:"cholinergic neuron") association path(MESH:Attention) View Subject | View Object

The cholinergic system is also involved in attention processes (Muir et al., 1993; Sarter and Bruno, 1997; Wenk, 1997) PubMed:25514383

Appears in Networks:

a(MESH:"Receptors, Cholinergic") increases path(MESH:Attention) View Subject | View Object

In a mouse model, the lack of ACh receptors in the prefrontal cortex (PFC) was demonstrated to be responsible for attention deficit, restored by the expression of the receptor in this area (Guillem et al., 2011) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Prefrontal Cortex

p(MGI:Chrnb2) increases path(MESH:Attention) View Subject | View Object

Null mutant beta2 mice were also tested to determine the role of this subunit in cognition. Guillem et al. (2011) showed that these mice exhibit an attention deficit which was restored by re-expression of this subunit with a lentiviral vector in the PFC PubMed:25514383

Appears in Networks:

a(HBP:"GTS-21") increases path(MESH:Attention) View Subject | View Object

It improves sensory inhibition in schizophrenics and also moderately improves their neuropsychological deficits in attention (Olincy et al., 2006) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Schizophrenia

a(CHEBI:nicotine) increases path(MESH:Attention) View Subject | View Object

Acute administration of nicotine to AD patients has resulted in a measurable short-term improvement in learning, memory, and attentional performance (Jones et al 1992) PubMed:11230871

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:Attention) View Subject | View Object

initially evaluated in normal subjects, GTS-21 was found to significantly improve attention and memory. in a second Phase i trial187, GTS-21 normalized P50 auditory gating in patients with schizophrenia. PubMed:19721446

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Smoking Cessation") decreases path(MESH:Attention) View Subject | View Object

(-)-Nicotine withdrawal symptoms might begin within a few hours after the last nicotine product, and include irritability/anger/stress/anxiety, sleep disturbances, depressed mood, craving, cognitive and attention deficits, and increased appetite. PubMed:28391535

Appears in Networks:

Out-Edges 5

path(MESH:Attention) association path(MESH:Schizophrenia) View Subject | View Object

The hallmark psychotic symptoms of SZ are the positive cluster and include auditory hallucinations, delusional beliefs, and disorganized thoughts and speech. SZ patients also exhibit negative symptoms, including anhedonia, dysfunctional social interactions, and poverty of thoughts and speech, as well as cognitive disturbances affecting several behavioral domains, including working memory, attention, and executive function PubMed:24511233

Appears in Networks:

path(MESH:Attention) association p(FPLX:CHRN) View Subject | View Object

By modulating activity-dependent events, nAChRs participate in fundamental aspects of synaptic plasticity that are involved in attention, learning, memory, and development (3, 12–16). PubMed:17009926

Appears in Networks:

path(MESH:Attention) association bp(GO:"synaptic transmission, cholinergic") View Subject | View Object

The cholinergic system is involved in critical physiological processes, such as attention, learning, memory, stress response, wakefulness and sleep, and sensory information PubMed:26813123

Appears in Networks:

path(MESH:Attention) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") View Subject | View Object

Members of the mAChR family are widely expressed in various regions in the central nervous system (CNS) and in the peripheral system. They play crucial roles in diverse physiological processes such as memory, attention, nociception, motor control, sleep-wake cycles, and cardiovascular, renal, and gastrointestinal functions PubMed:24590577

Appears in Networks:

path(MESH:Attention) association a(HP:"cholinergic neuron") View Subject | View Object

The cholinergic system is also involved in attention processes (Muir et al., 1993; Sarter and Bruno, 1997; Wenk, 1997) PubMed:25514383

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.