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a(CHEBI:"(-)-cotinine")

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Entity

Name
(-)-cotinine
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 2

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

Discriminative Stimulus Properties of S(−)-Nicotine: “A Drug for All Seasons v1.0.0

In-Edges 1

bp(GO:"nicotine metabolic process") increases a(CHEBI:"(-)-cotinine") View Subject | View Object

In humans, about 70–80% of nicotine is converted to the primary metabolite (-)-cotinine, a lactam derivative (Fig. 2). PubMed:28391535

Appears in Networks:

Out-Edges 5

a(CHEBI:"(-)-cotinine") increases bp(GO:memory) View Subject | View Object

Cotinine is a nicotine metabolite known for its positive effects on memory and attention and lower toxicity compared to nicotine (Hatsukami et al., 1997) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"(-)-cotinine") increases path(MESH:Attention) View Subject | View Object

Cotinine is a nicotine metabolite known for its positive effects on memory and attention and lower toxicity compared to nicotine (Hatsukami et al., 1997) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"(-)-cotinine") decreases path(MESH:"Plaque, Amyloid") View Subject | View Object

In a mouse model of AD, cotinine treatment decreased the plaque load and was able to activate the Akt pathway, that was shown to be neuroprotective (Echeverria et al., 2011) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"(-)-cotinine") increases act(p(FPLX:AKT)) View Subject | View Object

In a mouse model of AD, cotinine treatment decreased the plaque load and was able to activate the Akt pathway, that was shown to be neuroprotective (Echeverria et al., 2011) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"(-)-cotinine") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) View Subject | View Object

Cotinine is an alpha7 nAChR PAM (positive allosteric modulator) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.