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bp(MESH:"Blood Pressure")

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Entity

Name
Blood Pressure
Namespace
mesh
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/mesh-names.belns

Appears in Networks 2

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 7

p(HGNC:ACE) regulates bp(MESH:"Blood Pressure") View Subject | View Object

ACE, a membrane-bound zinc metalloprotease, catalyzes the transformation of angiotensin I to angiotensin II, which is beneficial to the maintenance of body fluid, blood pressure, and sodium balance PubMed:29626319

Appears in Networks:

p(HGNC:HBB) increases bp(MESH:"Blood Pressure") View Subject | View Object

Presence of any cell-free Hb limits NO diffusion from endothelium to smooth muscle cells for activation of guanylyl cyclase; as a consequence, mean arterial blood pressure increases.12,15 PubMed:27308950

Appears in Networks:
Annotations
MeSH
Arteries
Text Location
Introduction

p(HGNC:HBB) increases bp(MESH:"Blood Pressure") View Subject | View Object

SBP 315 increased 27±2 mmHg during the 40 minutes following infusion of hemoglobin in 316 db/db mice (Figure 4A). PubMed:28314763

Appears in Networks:
Annotations
MeSH
Diabetes Mellitus
Text Location
Introduction

p(HGNC:HPX) negativeCorrelation bp(MESH:"Blood Pressure") View Subject | View Object

Correlation analysis using Pearson’s correlation coefficient showed statistically significant inverse correlation between Hpx and blood pressure, both systolic (r = -0.511, pvalue< 0.00001, n = 145) and diastolic (r = -0,520, p-value<0.00001, n = 145)(Fig 3). PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Results

p(MGI:Hpx) decreases bp(MESH:"Blood Pressure") View Subject | View Object

In mouse models associated with 392 chronic hemolysis and heme overload, such as in mice with a sickle hemoglobin 393 (HbS) gene knock-in or mouse models of β-thalassemia, repeated treatment with 394 hemopexin was shown to reduce chronically elevated blood pressure (21). PubMed:28314763

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Arteries
MeSH
Diabetes Mellitus
Text Location
Introduction

complex(p(HGNC:HBB), p(MGI:Hp)) decreases bp(MESH:"Blood Pressure") View Subject | View Object

Co-administration of haptoglobin attenuated the hemoglobin-induced increase in SBP during the 40 minutes after co-injection by an average of 13±3 mmHg (Figure 1A). PubMed:28314763

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Text Location
Introduction

complex(p(HGNC:HBB), p(MGI:Hpx)) increases bp(MESH:"Blood Pressure") View Subject | View Object

SBP increased 224 on average 20±2 mmHg in mice injected with hemoglobin mixed with hemopexin and 225 therefore was similar to the increase after hemoglobin injection alone. PubMed:28314763

Appears in Networks:
Annotations
Text Location
Introduction

Out-Edges 1

bp(MESH:"Blood Pressure") negativeCorrelation p(HGNC:HPX) View Subject | View Object

Correlation analysis using Pearson’s correlation coefficient showed statistically significant inverse correlation between Hpx and blood pressure, both systolic (r = -0.511, pvalue< 0.00001, n = 145) and diastolic (r = -0,520, p-value<0.00001, n = 145)(Fig 3). PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.