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p(HGNC:ACE)

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Entity

Name
ACE
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Clearance systems in the brain-implications for Alzheimer disease. v1.0.1

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

In-Edges 1

path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:ACE)) View Subject | View Object

In addition, ACE expression also enhances Aβ clearance, and the levels and activity of ACE are elevated in AD brains (Barnes et al. 1991; Hemming and Selkoe 2005) PubMed:29626319

Appears in Networks:

Out-Edges 8

p(HGNC:ACE) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) View Subject | View Object

Extracellular Aβ can also be degraded by proteases, such as neprily- sin (a membrane-anchored zinc metalloendopeptidase that degrades the Aβ monomers Aβ1-40 and Aβ1-42, and Aβ oligomers),119 matrix metalloproteinases 2, 3 and 9,120 glutamate carboxypeptidase II,121 endothelin-converting enzyme,122 tissue plasminogen activator,123 plasmin,120 angiotensin-converting enzyme,120 and insulin-degrading enzyme. PubMed:26195256

Appears in Networks:

p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

Extracellular Aβ degrading enzymes include neprilysin (NEP), insulin-degrading enzyme (IDE), matrix metalloproteinases (MMPs), angiotensin converting enzyme (ACE), endothelin-converting enzyme (ECE), and plasmin (Baranello et al. 2015) PubMed:29626319

Appears in Networks:

p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

In addition, ACE expression also enhances Aβ clearance, and the levels and activity of ACE are elevated in AD brains (Barnes et al. 1991; Hemming and Selkoe 2005) PubMed:29626319

Appears in Networks:

p(HGNC:ACE) increases rxn(reactants(a(CHEBI:"Angiotensin I")), products(a(CHEBI:"angiotensin II"))) View Subject | View Object

ACE, a membrane-bound zinc metalloprotease, catalyzes the transformation of angiotensin I to angiotensin II, which is beneficial to the maintenance of body fluid, blood pressure, and sodium balance PubMed:29626319

Appears in Networks:

p(HGNC:ACE) regulates a(MESH:"Body Fluids") View Subject | View Object

ACE, a membrane-bound zinc metalloprotease, catalyzes the transformation of angiotensin I to angiotensin II, which is beneficial to the maintenance of body fluid, blood pressure, and sodium balance PubMed:29626319

Appears in Networks:

p(HGNC:ACE) regulates bp(MESH:"Blood Pressure") View Subject | View Object

ACE, a membrane-bound zinc metalloprotease, catalyzes the transformation of angiotensin I to angiotensin II, which is beneficial to the maintenance of body fluid, blood pressure, and sodium balance PubMed:29626319

Appears in Networks:

p(HGNC:ACE) regulates bp(GO:"sodium ion transmembrane transport") View Subject | View Object

ACE, a membrane-bound zinc metalloprotease, catalyzes the transformation of angiotensin I to angiotensin II, which is beneficial to the maintenance of body fluid, blood pressure, and sodium balance PubMed:29626319

Appears in Networks:

act(p(HGNC:ACE)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

In addition, ACE expression also enhances Aβ clearance, and the levels and activity of ACE are elevated in AD brains (Barnes et al. 1991; Hemming and Selkoe 2005) PubMed:29626319

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.