act(p(HGNC:MAPK1), ma(kin)) positiveCorrelation act(p(HGNC:CDK5), ma(kin))

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PubMed:25001178

Since Erk1/2 activity has been shown to induce cdk5 (Harada et al, 2001), miR-125b-induced Erk1/2 activation through DUSP6 downregulation might ultimately stimulate aberrant cdk5/p35 activation and, consequently, enhance pathological tau phosphorylation at multiple sites

Related Edges 3

• act(p(HGNC:CDK5), ma(kin)) positiveCorrelation act(p(HGNC:MAPK1), ma(kin))
• act(p(HGNC:DUSP6)) negativeCorrelation act(p(HGNC:MAPK1), ma(kin))
• act(p(HGNC:MAPK1), ma(kin)) negativeCorrelation act(p(HGNC:DUSP6))

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