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bp(MESH:"Neuronal Plasticity")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Neuronal Plasticity
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 4

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia. v1.0.0

This file encodes the article Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer’s disease and schizophrenia by Choi et al, 2014

Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017

In-Edges 8

a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(MESH:"Neuronal Plasticity") View Subject | View Object

It was then recognized that Ca2+ flux directly through nAChR channels or indirectly via voltage-gated Ca2+ channels is relevant for nicotinic modulation of transmitter release, synaptic plasticity, as well as neuronal viability, differentiation, and migration. PubMed:19126755

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Text Location
Review

a(CHEBI:"kynurenic acid") regulates bp(MESH:"Neuronal Plasticity") View Subject | View Object

Acting as an endogenous regulator of the alpha7 nAChR activity, astrocyte-derived KYNA can modulate synaptic transmission, synaptic plasticity, neuronal viability, and neuronal connectivity in different areas of the brain (Fig. 8). PubMed:19126755

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Review

act(p(FPLX:CREB)) association bp(MESH:"Neuronal Plasticity") View Subject | View Object

Recent studies have supported a role for ERK and CREB activity in neural plasticity associated with nicotine addiction (71, 381, 484). It has also been proposed that the ERK and JAK-2/STAT-3 signaling pathways contribute to the toxic effects of nicotine in skin cells (42), and other pathways contribute to the effects of nicotine and other nicotinic ligands on inflammatory responses as described below. PubMed:19126755

Appears in Networks:
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Text Location
Review

act(p(HGNC:MAPK1)) association bp(MESH:"Neuronal Plasticity") View Subject | View Object

Recent studies have supported a role for ERK and CREB activity in neural plasticity associated with nicotine addiction (71, 381, 484). It has also been proposed that the ERK and JAK-2/STAT-3 signaling pathways contribute to the toxic effects of nicotine in skin cells (42), and other pathways contribute to the effects of nicotine and other nicotinic ligands on inflammatory responses as described below. PubMed:19126755

Appears in Networks:
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Text Location
Review

p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") regulates bp(MESH:"Neuronal Plasticity") View Subject | View Object

N-methyl-D-aspartate (NMDA) receptors play a critical role in regulating synaptic plasticity, and disrupted NMDA-receptor neurotransmission is thought to underlie the cognitive deficits observed in numerous psychiatric diseases. PubMed:24511233

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tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) association bp(MESH:"Neuronal Plasticity") View Subject | View Object

These results suggest that tau translocates from the dendritic shaft to the synapse during activation and probably takes part in the activity-driven synaptic reorganization that underlies synaptic plasticity PubMed:24760868

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Text Location
Results

p(HGNC:MAPT) regulates bp(MESH:"Neuronal Plasticity") View Subject | View Object

We observed a similar LTPinduced increase in tau content within the PSD-enriched fraction from CA1 synaptosomes (29.86 +-4.86 to 70.15 +- 4.86, **p = 0.0011; Fig. 3B). As expected, actin and GluA1 were also increased, strengthening the idea that tau is involved in synaptic reorganization processes necessary for synaptic plasticity PubMed:24760868

Appears in Networks:
Annotations
MeSH
Post-Synaptic Density
Text Location
Results

a(HBP:"Tau aggregates") association bp(MESH:"Neuronal Plasticity") View Subject | View Object

A recent study showed that neuronal networks facilitate cell-to-cell transfer of tau via synapses; using a microfluidic device they demonstrated that decreasing synaptic connections weakens tau transfer and the subsequent aggregation on the acceptor cell (Calafate et al., 2015) PubMed:28420982

Appears in Networks:
Annotations
Confidence
Low
MeSH
Entorhinal Cortex

Out-Edges 5

bp(MESH:"Neuronal Plasticity") association act(p(FPLX:CREB)) View Subject | View Object

Recent studies have supported a role for ERK and CREB activity in neural plasticity associated with nicotine addiction (71, 381, 484). It has also been proposed that the ERK and JAK-2/STAT-3 signaling pathways contribute to the toxic effects of nicotine in skin cells (42), and other pathways contribute to the effects of nicotine and other nicotinic ligands on inflammatory responses as described below. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

bp(MESH:"Neuronal Plasticity") association act(p(HGNC:MAPK1)) View Subject | View Object

Recent studies have supported a role for ERK and CREB activity in neural plasticity associated with nicotine addiction (71, 381, 484). It has also been proposed that the ERK and JAK-2/STAT-3 signaling pathways contribute to the toxic effects of nicotine in skin cells (42), and other pathways contribute to the effects of nicotine and other nicotinic ligands on inflammatory responses as described below. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

bp(MESH:"Neuronal Plasticity") association tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) View Subject | View Object

These results suggest that tau translocates from the dendritic shaft to the synapse during activation and probably takes part in the activity-driven synaptic reorganization that underlies synaptic plasticity PubMed:24760868

Appears in Networks:
Annotations
Text Location
Results

bp(MESH:"Neuronal Plasticity") increases tloc(p(HGNC:MAPT), fromLoc(GO:cell), toLoc(GO:cell)) View Subject | View Object

A recent study showed that neuronal networks facilitate cell-to-cell transfer of tau via synapses; using a microfluidic device they demonstrated that decreasing synaptic connections weakens tau transfer and the subsequent aggregation on the acceptor cell (Calafate et al., 2015) PubMed:28420982

Appears in Networks:
Annotations
Confidence
Low
MeSH
Entorhinal Cortex

bp(MESH:"Neuronal Plasticity") association a(HBP:"Tau aggregates") View Subject | View Object

A recent study showed that neuronal networks facilitate cell-to-cell transfer of tau via synapses; using a microfluidic device they demonstrated that decreasing synaptic connections weakens tau transfer and the subsequent aggregation on the acceptor cell (Calafate et al., 2015) PubMed:28420982

Appears in Networks:
Annotations
Confidence
Low
MeSH
Entorhinal Cortex

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.