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a(MESH:"Cell Membrane")

Equivalencies: 0 | Classes: 1 | Children: 0 | Explore

Entity

Name
Cell Membrane
Namespace
mesh
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns

Appears in Networks 6

Alpha-synuclein oligomers: a new hope v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017

Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology v1.0.0

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer v1.0.0

PP2A and Alzheimer Disease v1.0.0

In-Edges 7

a(HBP:HBP00093) decreases a(MESH:"Cell Membrane") View Subject | View Object

A-syn oligomers can stabilize membrane defects accelerating membrane damage [19] and can alter membrane properties such as input resistance reducing neuronal excitability [72] PubMed:28803412

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

complex(a(GO:vesicle), a(MESH:"Cell Membrane")) hasComponent a(MESH:"Cell Membrane") View Subject | View Object

Appears in Networks:

complex(a(MESH:"Cell Membrane"), p(HGNC:MAPT)) hasComponent a(MESH:"Cell Membrane") View Subject | View Object

Appears in Networks:

complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) hasComponent a(MESH:"Cell Membrane") View Subject | View Object

Appears in Networks:

p(HGNC:ANXA2) association a(MESH:"Cell Membrane") View Subject | View Object

The data suggest that tau’s membrane association causes retention of tau in the tip of neurites, which is compromised by the R406W mutation. Also, after BAPTA treatment, the difference in the retention of wt tau and R406W tau was abolished (Fig. 9 D), which again suggests that tau trapping is caused by an interaction with AnxA2 at the membrane. PubMed:21339331

Appears in Networks:

p(HGNC:PPP2CA) association a(MESH:"Cell Membrane") View Subject | View Object

The isoform C α is predominantly expressed in the plasma membrane and C β in the cytoplasm and nucleus. PubMed:23454242

Appears in Networks:

p(FPLX:PPP2) association a(MESH:"Cell Membrane") View Subject | View Object

PP2A is mainly pre- sent as a soluble protein in the cytosol but it is also encoun- tered in the nucleus, mitochondria, cytoskeleton, and mem- branes. PubMed:22299660

Appears in Networks:

Out-Edges 4

a(MESH:"Cell Membrane") association p(HGNC:PPP2CA) View Subject | View Object

The isoform C α is predominantly expressed in the plasma membrane and C β in the cytoplasm and nucleus. PubMed:23454242

Appears in Networks:

a(MESH:"Cell Membrane") association p(HGNC:ANXA2) View Subject | View Object

The data suggest that tau’s membrane association causes retention of tau in the tip of neurites, which is compromised by the R406W mutation. Also, after BAPTA treatment, the difference in the retention of wt tau and R406W tau was abolished (Fig. 9 D), which again suggests that tau trapping is caused by an interaction with AnxA2 at the membrane. PubMed:21339331

Appears in Networks:

a(MESH:"Cell Membrane") isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) View Subject | View Object

Appears in Networks:

a(MESH:"Cell Membrane") association p(FPLX:PPP2) View Subject | View Object

PP2A is mainly pre- sent as a soluble protein in the cytosol but it is also encoun- tered in the nucleus, mitochondria, cytoskeleton, and mem- branes. PubMed:22299660

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.