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Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:23:24.071569
Authors
Lingling Xu
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
28
Number Edges
38
Number Components
1
Network Density
0.0502645502645503
Average Degree
1.35714285714286
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0 33%
Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0 25%
Tau Modifications v1.9.5 21%
Alzheimer’s disease and the autophagic-lysosomal system v1.0.0 21%
The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0 21%
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation v1.0.0 18%
Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability v1.0.0 18%
Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0 18%
Inflammasome Involvement in Alzheimer’s Disease v1.0.0 14%
Tau in physiology and pathology v1.0.0 14%

Sample Edges

a(MESH:"Transport Vesicles") association p(HGNC:MAPT) View Subject | View Object

Rab7a (Rodriguez et al., 2017) and Rab1a (Mohamed et al., 2017) have been recently implicated in tau release, further suggesting that tau release involves vesicle transport. PubMed:29238289

Annotations
MeSH
Blood
MeSH
Cerebrospinal Fluid

act(a(MESH:Exosomes)) association p(HGNC:MAPT) View Subject | View Object

Tau from the CSF (Saman et al., 2012) and blood of patients with AD (Fiandaca et al., 2015) is associated with exosomes PubMed:29238289

Annotations
MeSH
Blood
MeSH
Cerebrospinal Fluid

act(a(MESH:Lysosomes)) decreases p(HGNC:MAPT) View Subject | View Object

starvation or lysosomal dysfunction increases tau release PubMed:29238289

a(MESH:Microglia) increases p(HGNC:MAPT) View Subject | View Object

N2a cells over-expressing tau (Wang et al., 2017) and microglia also release tau in an exosome-dependent manner PubMed:29238289

Annotations
MeSH
Blood
MeSH
Cerebrospinal Fluid

act(a(MESH:Microtubules)) association p(HGNC:MAPT) View Subject | View Object

Tau is well-recognized for its role in assembling/stabilizing microtubules although tau single knockout mice do not show major phenotypic changes in neuronal microtubule stability because of a putative functional redundancy PubMed:29238289

Sample Nodes

a(MESH:Microglia)

In-Edges: 19 | Out-Edges: 25 | Explore Neighborhood | Download JSON

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON

path(MESH:Memory)

In-Edges: 6 | Out-Edges: 3 | Explore Neighborhood | Download JSON

p(HGNC:MAPT)

In-Edges: 477 | Out-Edges: 480 | Classes: 11 | Children: 27 | Explore Neighborhood | Download JSON

p(HGNC:CASP3)

In-Edges: 14 | Out-Edges: 17 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.