The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
|Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0||33%|
|Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0||25%|
|Tau Modifications v1.9.5||21%|
|Alzheimer’s disease and the autophagic-lysosomal system v1.0.0||21%|
|The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0||21%|
|Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation v1.0.0||18%|
|Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability v1.0.0||18%|
|Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0||18%|
|Inﬂammasome Involvement in Alzheimer’s Disease v1.0.0||14%|
|Tau in physiology and pathology v1.0.0||14%|
starvation or lysosomal dysfunction increases tau release
Tau is well-recognized for its role in assembling/stabilizing microtubules although tau single knockout mice do not show major phenotypic changes in neuronal microtubule stability because of a putative functional redundancy
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.