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complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT))

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Components

Appears in Networks 1

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

In-Edges 4

a(MESH:"Cell Membrane") isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) View Subject | View Object

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p(HGNC:MAPT) isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) View Subject | View Object

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p(HGNC:ANXA2) isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) View Subject | View Object

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p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) View Subject | View Object

The data suggest that tau’s membrane association causes retention of tau in the tip of neurites, which is compromised by the R406W mutation. Also, after BAPTA treatment, the difference in the retention of wt tau and R406W tau was abolished (Fig. 9 D), which again suggests that tau trapping is caused by an interaction with AnxA2 at the membrane. PubMed:21339331

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Out-Edges 3

complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) hasComponent a(MESH:"Cell Membrane") View Subject | View Object

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complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) hasComponent p(HGNC:ANXA2) View Subject | View Object

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complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) hasComponent p(HGNC:MAPT) View Subject | View Object

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.