1. Catalog
  2. Nodes
  3. p(HGNC:BCL2, pmod(Ph))

p(HGNC:BCL2, pmod(Ph))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
BCL2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. v1.0.0

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer v1.0.0

In-Edges 3

p(HGNC:MAPK8) increases p(HGNC:BCL2, pmod(Ph)) View Subject | View Object

For instance, c-Jun NH 2-terminal kinase 1 (JNK1) may induce autophagy by phosphorylating Bcl-2 or Bim and abolishing their inhibitory effects on autophagy (Luo et al., 2012; Wei et al., 2008). PubMed:23528736

Appears in Networks:

p(HGNC:BCL2) hasVariant p(HGNC:BCL2, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(FPLX:PPP2) decreases p(HGNC:BCL2, pmod(Ph)) View Subject | View Object

Phosphorylation of BAD suppresses, and its dephosphorylation by PP2A promotes pro-apoptotic activity [59]. Additionally, phosphorylation of Bcl-2 activates, and its dephosphorylation by PP2A suppresses anti- apoptotic activity. PubMed:23454242

Appears in Networks:

Out-Edges 1

p(HGNC:BCL2, pmod(Ph)) decreases bp(GO:"apoptotic process") View Subject | View Object

Phosphorylation of BAD suppresses, and its dephosphorylation by PP2A promotes pro-apoptotic activity [59]. Additionally, phosphorylation of Bcl-2 activates, and its dephosphorylation by PP2A suppresses anti- apoptotic activity. PubMed:23454242

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.