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composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP))

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Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer v1.0.0

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Out-Edges 4

composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) hasComponent a(CHEBI:"magnesium(2+)") View Subject | View Object

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composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) hasComponent a(CHEBI:ATP) View Subject | View Object

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composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNCGENEFAMILY:Proteasome)) View Subject | View Object

For example, in the study where rat brain extract was incubated with Mg2+ and ATP, there was an overall decrease in tau due to proteasomal activity; however tau phosphorylated at the PHF1 and Tau-1 epitopes seemed to be preferentially degraded as they were non-detectable within 3 h (73). The preferential degradation of specific phospho-forms of tau by a particular pathway has been reported in other studies as well. PubMed:24027553

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Brain
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Review

composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNC:PPP2R3A)) View Subject | View Object

This group also requires ATP and Mg2+ to activate its own activity. PubMed:23454242

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.