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Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-03-15 15:44:07.886932
Authors
Esther Wollert
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
11
Number Edges
16
Number Components
2
Network Density
0.145454545454545
Average Degree
1.45454545454545
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0 50%
Tau in physiology and pathology v1.0.0 45%
Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0 45%
Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0 45%
Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0 45%
Tau oligomers and tau toxicity in neurodegenerative disease v1.0.0 45%
Tau Modifications v1.9.5 45%
Caenorhabditis elegans models of tauopathy v1.0.0 36%
Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition v1.0.1 36%
Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways v1.0.1 36%

Sample Edges

a(CHEBI:"sodium chlorate") decreases complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) View Subject | View Object

Heparin blocks Tau binding by masking HSPG binding sites on Tau, and sodium chlorate inhibits HSPG sulfation. PubMed:25887395

a(CHEBI:"sodium chlorate") decreases a(HBP:"Tau aggregates") View Subject | View Object

To test whether HSPGs also mediate BD Tau seeding, we titrated heparin and sodium chlorate, which inhibited seeding of all species (Fig. 8D). PubMed:25887395

a(CHEBI:heparin) decreases complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) View Subject | View Object

Heparin blocks Tau binding by masking HSPG binding sites on Tau, and sodium chlorate inhibits HSPG sulfation. PubMed:25887395

a(CHEBI:heparin) decreases a(HBP:"Tau aggregates") View Subject | View Object

To test whether HSPGs also mediate BD Tau seeding, we titrated heparin and sodium chlorate, which inhibited seeding of all species (Fig. 8D). PubMed:25887395

a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Whereas control brain homogenate exhibited mainly Tau monomer, the AD brain contained a range of Tau assemblies ranging from n = 1 to n > 20 (Fig. 7, A and B). PubMed:25887395

Annotations
MeSH
Brain

Sample Nodes

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON

p(HGNC:MAPT)

In-Edges: 477 | Out-Edges: 480 | Classes: 11 | Children: 27 | Explore Neighborhood | Download JSON

a(HBP:"Tau aggregates")

In-Edges: 224 | Out-Edges: 71 | Children: 3 | Explore Neighborhood | Download JSON

a(HBP:"Tau fibrils")

In-Edges: 19 | Out-Edges: 3 | Explore Neighborhood | Download JSON

a(HBP:"Tau oligomers")

In-Edges: 85 | Out-Edges: 62 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.