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a(CHEBI:"magnesium(2+)") decreases complex(a(CHEBI:"calcium(2+)"), p(GFAM:"Glutamate ionotropic receptor NMDA type subunits")) View Subject | View Object

In individuals with normal cognitive functioning, Mg2+ blocks the passage of Ca2+ through the neuronal NMDA receptor calcium channel under resting conditions, but it is readily displaced when membrane depolarization occurs and synaptic glutamate concentrations are at peak levels (ie, when neuronal firing occurs). PubMed:16273023


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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.