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Appears in Networks 4

In-Edges 4

act(p(HGNC:HTRA1)) association act(a(MESH:Microtubules)) View Subject | View Object

Tubulin was later identified as a substrate for HTRA1, suggesting HTRA1 may be involved in mediating microtubule function (42, 43). A more recent study showed that HTRA1 can cleave recombinant tau in vitro into multiple fragments of varying sizes, and furthermore can degrade insoluble and fibrillarized tau (16). PubMed:24027553

p(HGNC:MAPT) association act(a(MESH:Microtubules)) View Subject | View Object

Tau is well-recognized for its role in assembling/stabilizing microtubules although tau single knockout mice do not show major phenotypic changes in neuronal microtubule stability because of a putative functional redundancy PubMed:29238289

Out-Edges 2

act(a(MESH:Microtubules)) association act(p(HGNC:HTRA1)) View Subject | View Object

Tubulin was later identified as a substrate for HTRA1, suggesting HTRA1 may be involved in mediating microtubule function (42, 43). A more recent study showed that HTRA1 can cleave recombinant tau in vitro into multiple fragments of varying sizes, and furthermore can degrade insoluble and fibrillarized tau (16). PubMed:24027553

act(a(MESH:Microtubules)) association p(HGNC:MAPT) View Subject | View Object

Tau is well-recognized for its role in assembling/stabilizing microtubules although tau single knockout mice do not show major phenotypic changes in neuronal microtubule stability because of a putative functional redundancy PubMed:29238289

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.